Meeting abstract
Association between systemic inflammatory indices (NLR, PLR, SII, SIRI) and handicap severity in acute unilateral peripheral vestibulopathy
Luka Županović
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Boris Šimunjak
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Tereza Cvjetko
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Jurica Putrić Posavec
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Ivan Mesar
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Luka Blažević
; KB Sveti Duh, Ulica Sveti Duh 64, 10000 Zagreb, Hrvatska
Abstract
Background/Objectives: Acute unilateral peripheral vestibulopathy (AUVP) is the third most common cause
of peripheral vestibular vertigo, with presumed viral etiology and considerable symptom burden. This study
examined the association between systemic immune-inflammatory biomarkers, including the neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and
systemic inflammation response index (SIRI), and dizziness-related disability in AUVP, as assessed by the
Dizziness Handicap Inventory (DHI). Methods: This retrospective single-center cohort study was conducted
at Sveti Duh Clinical Hospital, Zagreb, from January 2021 to May 2025, including 45 AUVP patients and 45
healthy controls. Laboratory parameters were obtained from which the following indices were calculated:
NLR, PLR, SII, and SIRI. Symptom severity was evaluated with the DHI, and patients were stratified into
severe and non-severe groups. Group comparisons and receiver operating characteristic (ROC) analyses were
performed to assess discriminatory value. Results: Compared with controls, AUVP patients showed
significantly higher leukocyte and neutrophil counts, as well as elevated inflammatory indices. DHI analysis
revealed the Physical domain had the greatest impact, followed by the Functional domain, whereas the
Emotional domain was less affected. Severe cases exhibited significantly higher NLR, PLR, and SII values.
ROC analysis identified PLR as the most accurate predictor of severe dizziness-related disability (AUC=0.81),
followed by SII (AUC=0.73) and NLR (AUC=0.67). Conclusion: Inflammatory indices, particularly PLR,
NLR, and SII, are associated with greater dizziness-related disability in AUVP. These readily available, costeffective biomarkers may support risk stratification and highlight the contribution of immune-inflammatory
mechanisms to AUVP pathophysiology.
Keywords
acute unilateral vestibulopathy; DHI, systemic inflammatory indices; vestibular neuritis
Hrčak ID:
336453
URI
Publication date:
10.11.2025.
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