Original scientific paper
https://doi.org/https://doi.org/10.5599/jese.3447
Co-detection of isoproterenol and uric acid in biological and pharmaceutical samples at modified carbon paste electrode
Marib Ismail Ali
; Department of Chemistry, College of Education, University of Tikrit, Iraq
*
Ghofran Ali
; Ministry of Education, General Directorate of Education, Najaf, Iraq
Noor Hameed Neama Aziz
; Ministry of Education, General Directorate of Education, Najaf, Iraq
* Corresponding author.
Abstract
In this study, cyclic voltammetry was used to examine the electrochemical characteristics of a carbon paste electrode modified with a manufactured Ni-based 1,3,5-benzenetricarboxylate metal-organic framework nanostructure/graphene oxide nanocomposite. The modified electrode demonstrated outstanding electrocatalytic activity toward isoproterenol (IPT), with superior electrochemical performance, low overpotential, and high conductivity when used as an electrochemical sensor for the catalytic oxidation of IPT. It was found that under ideal conditions (pH 7.0), the oxidation potential of IPT would drop to approximately 170 mV at the modified electrode compared with an unmodified carbon paste electrode. A linear concentration range, 0.05 to 480.0 μM IPT, was demonstrated using differential pulse voltammetry. It was discovered that the IPT detection limit was 0.015 μM. To determine IPT in the presence of uric acid (UA), the selectivity of the developed electrochemical sensor was also examined. Ultimately, the developed sensor was used to detect IPT and UA in genuine drug samples and human urine, yielding satisfactory findings.
Keywords
Heart attacks; bronchitis; cardiac shock; voltammetry; catecholamines; drug analysis; urine analysis
Hrčak ID:
351722
URI
Publication date:
11.8.2026.
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