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Croatian Journal of Infection, Vol. 43 No. 3, 2023.

Case report, case study

https://doi.org/10.37797/ig.43.3.4

Acute-On-Chronic Liver Failure Triggered by Dobrava Hantavirus Infection: A Case Report

Sara Šundalić ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia *
Ozrenka Zlopaša ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Martina Čalušić ; Liver Transplant Unit, University Hospital Centre Zagreb, Zagreb, Croatia; Department of Anaesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Anna Mrzljak ; Liver Transplant Unit, University Hospital Centre Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Igor Petrović ; Liver Transplant Unit, University Hospital Centre Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia
Tina Tomić Mahečić ; Liver Transplant Unit, University Hospital Centre Zagreb, Zagreb, Croatia; Department of Anaesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Iva Košuta ; Division of Intensive Care Medicine, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia; Liver Transplant Unit, University Hospital Centre Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

* Corresponding author.

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Abstract

Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome characterised by acute worsening of liver function and extrahepatic organ failure in patients with chronic liver disease. Bacterial infections are the most common trigger; however, viral and zoonotic pathogens remain underrecognized causes. We present a case of ACLF precipitated by presumed Dobrava hantavirus infection, complicated by haemorrhagic shock, acute kidney injury, and fatal outcome.

Keywords

Dobrava virus; haemorrhagic fever with renal syndrome; acute-on-chronic liver failure; liver cirrhosis; liver transplantation

Hrčak ID:

352446

URI

https://hrcak.srce.hr/352446

Publication date:

19.10.2026.

Article data in other languages: croatian

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