Short communication, Note

https://doi.org/10.2478/v10007-009-0009-8

Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals

AMANY HASSAN M. EL SHAZLY ; Department of Pharmacology, Research Institute of Ophthalmology, Giza, Egypt
ATEF MOHAMED MAHMOUD ; Department of Biochemistry, Research Institute of Ophthalmology, Giza, Egypt
NEVINE SALAH DARWISH ; Department of Histology, Research Institute of Ophthalmology, Giza, Egypt

Abstract

This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes. Four groups of Wistar rats, each composed of ten rats, were used. Two groups served as control. In group 3, diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg kg1). In group 4, diabetes was induced and treated with aminoguanidine 100 mg kg1 daily orally for 3 months. Levels of serum glucose, glutathione peroxidase, glutathione reductase and erythrocytes catalase were analyzed on day 90 of the experiment. Retinal and kidney specimens were examined histopathologically after sacrifice of the animals. A significant antioxidant effect of aminoguanidine and its prophylactic role in diabetic retinopathy and nephropathy were observed in experimental animals.

Keywords

aminoguanidine; diabetic retinopathy; nephropathy; nitric oxide; glycated end product; antioxidants

Hrčak ID:

32297

URI

https://hrcak.srce.hr/32297

Publication date:

1.3.2009.

Article data in other languages: croatian

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