Original scientific paper
Vascular Endothelial Growth Factor in Aqueous Humor of Patients with Perforative Eye Injuries
Maja Merlak
Damir Kovačević
Tihomir Balog
Tanja Marotti
Renata Grčetić Lenac
Ivana Romac
Iva Dekaris
Abstract
Considering that VEGF is the key factor for angiogenesis stimulation, we wanted to establish if VEGF level is increased
in aqueous humor of patients with open globe eye injury. The study included 20 patients with open globe injury.
During the surgery, aqueous humor samples were taken out and VEGF levels were measured by ELISA. VEGF levels
were significantly higher in the aqueous humor of patients with open globe eye injury and uveitis, in patients with
wound bigger than 2 mm and in patients where from injury to surgery passed more than 4 hours. VEGF levels were also
higher, but not significantly, in patients with intrabulbar foreign body. Considering that VEGF levels were significantly
higher in patients with open globe eye injury with uveitis, wound larger than 2 mm and in patients where from injury to
surgery passed more than 4 hours, anti VEGF therapy might have application in these conditions.
Keywords
vascular endothelial growth factor; aqueous humor; perforative eye injury
Hrčak ID:
34536
URI
Publication date:
1.10.2008.
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