Croatica Chemica Acta, Vol. 78 No. 3, 2005.
Original scientific paper
Effect of Hyperbaric Oxygenation on the Level of Free Fatty Acids in Experimental Spinal Cord Injury in Rabbits
Radojka Pantović
Pero Draganić
Vesna Eraković
Branka Blagović
Čedomila Milin
Ante Simonić
Abstract
The aim of this study was to investigate the influence of hyperbaric oxygenation treatment (HBOT), a potent inhibitor of tissue hypoxia, on the motor activity and the spinal cord tissue concentration of free palmitic (C16:0), stearic (C18:0), oleic (C18:1n-9), arachidon (C20:4n-6) and docosahexaenoic (C22:6n-3) acids, in rabbits with spinal cord injury (SCI). SCI resulted in paraplegia and accumulation of all analyzed free fatty acids (FFAs) in the spinal cord after neurotrauma. HBOT (222.915 kPa pressure of 99.5 % oxygen for 45 min), applied immediately after injury and followed by 8 consecutive daily treatments, improved motor impairment and completely prevented the SCI-induced increase in FFAs. These data suggest that a perturbation of the membrane lipid metabolism may contribute to the functional deficit associated with SCI, and HBOT may protect the injured spinal cord tissue, at least in part, by limiting these posttraumatic membrane lipid changes.
Keywords
free fatty acids; hyperbaric oxygenation; spinal cord injury; rabbit
Hrčak ID:
57
URI
Publication date:
15.9.2005.
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