Acta clinica Croatica, Vol. 48 No. 2, 2009.
Other
Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report
Marina Titlić
Ivana Jukić
Ante Tonkić
Ante Buča
Anka Aleksić-Shihabi
Abstract
Radicular pain syndromes caused by disk herniation are often accompanied by incomplete central cord syndrome. Intensive pain is difficult to control with standard analgesics. Antiepileptics of new generation have shown significant efficacy in treating pain syndromes, trigeminal neuralgia, diabetic neuropathy, migraines, etc. The treatment of radicular pain with lamotrigine, a new generation antiepileptic, turned out to be effective in lumbar disk radicular conflicts, justifying its application for resistant pain in cervical segment. In our patient, pain intensity was significantly reduced with gradual titration of lamotrigine to a dose of 200 mg/day. Pain intensity measured by the visual analog scale significantly decreased from 100 to 20 mm during eight weeks of titration. The blood concentration of the drug measured by the method of high performance liquid chromatography was 13.65 µmol/L. The patient.s quality of life improved greatly. It is necessary to further evaluate the efficacy of lamotrigine in the treatment of resistant radicular damage.
Keywords
Spinal cord diseases - therapy; Neuralgia - physiopathology; Neuralgia - drug therapy; Anticonvulsants - pharmacology; Pain - drug therapy
Hrčak ID:
40952
URI
Publication date:
1.7.2009.
Visits: 1.947 *