Original scientific paper

https://doi.org/10.2478/v10007-010-0009-8

Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles

ADEL H. MANDOUR ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
ESLAM R. EL-SAWY ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
KAMEL H. SHAKER ; Organic Chemistry NWII,1/2, University of Bayreuth, Bayreuth, Germany
MOHAMED A. MUSTAFA ; Research Unit, Egypt Pharmacist Co., Cairo, Egypt

Abstract

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

Keywords

indole-3-carboxaldehyde; anti-inflammatory activity; anticonvulsant activity; analgesic activity

Hrčak ID:

48283

URI

https://hrcak.srce.hr/48283

Publication date:

1.3.2010.

Article data in other languages: croatian

Visits: 2.713 *