Original scientific paper

Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives

DAVORKA BALLIAN KRZNAR
JELENA FILIPOVIĆ-GRČIĆ
BRANKA ZORC
MARIJANA ZOVKO

Abstract

A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly,-(N-2-hydroxyethyl-DL-aspartamide) (PHEA, 1) and its thiolated analogue poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.

Keywords

celecoxib; disks; polyaspartamide; thiomer

Hrčak ID:

4608

URI

https://hrcak.srce.hr/4608

Publication date:

1.12.2006.

Article data in other languages: croatian

Visits: 2.207 *