Original scientific paper

Evaluation of a drug with wax like properties as a melt binder

RAVINDRA S. DHUMAL
SHAMKANT L. SHIMPI
BHASKAR CHAUHAN
KAKASAHIB R. MAHADIK
ANANT PARADKAR

Abstract

The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr’s index, Hausner’s ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation technique

Keywords

ibuprofen; binder; melt granulation

Hrčak ID:

4609

URI

https://hrcak.srce.hr/4609

Publication date:

1.12.2006.

Article data in other languages: croatian

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