Original scientific paper
Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy
Mladen Lešin
; Eye Department, University Hospital Center Split, Split, Croatia
Lovro Bojić
; Eye Department, University Hospital Center Split, Split, Croatia
Rinaldo Romac
; Department of Neurology, University Hospital Center Split, Split, Croatia
Joško Leštin
; Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia
Milan Ivanišević
; Eye Department, University Hospital Center Split, Split, Croatia
Davor Galetović
; Eye Department, University Hospital Center Split, Split, Croatia
Veljko Rogošić
; Eye Department, University Hospital Center Split, Split, Croatia
Abstract
The aim of this study was to evaluate the effects of extraocular muscle injection of botulinum toxin-A (BTX-A) on intraocular pressure (IOP) and proptosis in patients with ocular motility disturbances in thyroid associated orbitopathy (TAO). In 17 patients (20 eyes) with restrictive strabismus and diplopia, BTX -A injections were applied. Intraocular pressure was measured with a Goldmann applanation tonometer in primary gaze position before and 2–4 weeks after BTX-A injection. Extraorbital prominention of the eyeball was measured before and after BTX -A injection using a Hertel instrument. Before the injection, the mean IOP in primary position of gaze was 18.6± 2.8 mmHg and 2–4 weeks after BTX-A injection was 16.9±3.3 mmH; (p=0.001). There was no statistically significant difference in Hertel egzophthalmometer readings before and after BTX-A injection, 21.5±2.7 mm vs 22.0± 2.6 mm; (p=0.678). In conclusion, BTX-A injection has a secondary lowering effect on IOP in TAO due to relaxation of extraocular muscles, but with no influence on proptosis.
Keywords
thyroid related orbitopathy; botulinum toxin-A; intraocular pressure; proptosis
Hrčak ID:
51483
URI
Publication date:
1.12.2009.
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