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Review article

Recent Achievements in Simulated Moving Bed (SMB) Technology. Part I.

V. Šunjić ; Chirallica Ltd., Zagreb, Croatia
D. Franić ; Chirallica Ltd., Zagreb, Croatia
D. Kontrec ; Ruđer Bošković Institute, Zagreb, Croatia
M. Roje ; Ruđer Bošković Institute, Zagreb, Croatia

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Simulated moving bed (SMB) technology is over half a century known in continuous chromatographic separation of binary mixtures. Invented and developed in the petrochemical and sugar industries, it was recognized by organic chemists in the pharmaceutical industry as a powerful tool in separation of racemic mixtures. Over the years, it was developed into a standard laboratory, then pilot-plant and finally large-scale method for production of chiral compounds in the optically pure form. Final products of this technology are enantiopure drugs, other biologically active compounds and their intermediates. In Part I of this review, the basic principles and selected examples of recent SMB technology applications are presented.


simulated moving bed, continuous chromatography, triangle theory, enantioseparation

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