Izvorni znanstveni članak
https://doi.org/10.15255/KUI.2018.014
Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling
Marko Trampuž
orcid.org/0000-0002-1335-6474
; Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia
Dušan Teslić
; Sandoz Development Centre Slovenia, Lek d. d., Kolodvorska 27, 1234 Mengeš, Slovenia
Blaž Likozar
; Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia
Sažetak
Development of a mathematical model for batch crystallization of fesoterodine fumarate, an active pharmaceutical ingredient, in 2-butanone is presented. The model is based on population, mass and energy balances, and takes into account nucleation, crystal growth and agglomeration. Equilibrium solubility was determined experimentally by ATR-FTIR spectroscopy. Kinetic parameters were determined by fitting of experimental and simulated concentration curves and particle size distributions for six crystallization experiments, performed under different operating conditions. The model was validated and the results show good agreement with experimental data.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ključne riječi
pharmaceutical; crystallization; modelling; kinetics; equilibrium; fesoterodine fumarate
Hrčak ID:
207029
URI
Datum izdavanja:
14.12.2018.
Posjeta: 1.536 *