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IMMUNOHISTOCHEMICAL EXPRESSION OF BROTHER OF THE REGULATOR OF IMPRINTED SITES (BORIS) IN TESTICULAR GERM CELL TUMORS

ANA MESIĆ orcid.org/0000-0002-6144-2780 ; Zavod za hitnu medicinu Krapinsko-zagorske županije, Krapina, Hrvatska
IVANA MILOŠEVIĆ orcid.org/0000-0002-0369-930X ; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska
VIBOR MILUNOVIĆ ; Klinička bolnica Merkur, Zavod za hematologiju, Zagreb, Hrvatska
MILAN MILOŠEVIĆ orcid.org/0000-0001-9008-7645 ; Sveučilište u Zagrebu, Medicinski fakultet, Škola narodnog zdravlja “Andrija Štampar”, Zagreb, Hrvatska
MONIKA ULAMEC orcid.org/0000-0002-4843-8154 ; Klinički bolnički centar “Sestre milosrdnice”, Zavod za patologiju i citologiju, Zagreb i Sveučilište u Zagrebu, Medicinski fakultet, Zavod za patologiju, Zagreb, Hrvatska
BOŽO KRUŠLIN orcid.org/0000-0002-0480-1687 ; Klinički bolnički centar “Sestre milosrdnice”, Zavod za patologiju i citologiju, Zagreb i Sveučilište u Zagrebu, Medicinski fakultet, Zavod za patologiju, Zagreb, Hrvatska

Sažetak

Brother of the Regulator of Imprinted Sites (BORIS) has a role in intracellular signalization and is important in epigenetic mechanism control, such as methylation/demethylation of DNA and histones. BORIS may deregulate some tumor suppressor genes. Immunohistochemical expression of BORIS was found in different tumors, some of them showing correlation with poor prognosis. The aim of this study was to determine immunohistochemical expression of BORIS in pure seminomas and different components of testicular mixed germ cell tumors (MGCT). In this study, immunohistochemical expression of BORIS in testicular germ cell tumors (TGCT) was analyzed. Staining intensity and percentage of positive staining cells were used to evaluate the level of expression. Tumor samples from 44 patients were analyzed; 26 pure seminomas and 18 MGCT. In MGCTs, seminoma component was found in 4, yolk sac in 7, teratoma in 11 and embryonal carcinoma in 13 samples. Expression of BORIS was strong in 80.8% of seminoma cases and in 76.9% of embryonal carcinoma component, 71.4% of yolk sac, 63.6% of teratoma component and 25% of seminomatous component of MGCT. In MGCT, positive correlation was found between BORIS expression in teratomatous component and presence of yolk sac component (

Ključne riječi

BORIS; testicular germ cell tumors; immunohistochemistry; biomarkers

Hrčak ID:

216410

URI

https://hrcak.srce.hr/216410

Datum izdavanja:

30.1.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.357 *