Acta Pharmaceutica, Vol. 69 No. 4, 2019.
Izvorni znanstveni članak
https://doi.org/10.2478/acph-2020-0048
Antiproliferative evaluation of various aminoquinoline derivatives
BRANKA ZORC
; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia
ZRINKA RAJIĆ
; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia
IVANA PERKOVIĆ
; University of Zagreb Faculty of Pharmacy, 10 000 Zagreb, Croatia
Sažetak
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.
Ključne riječi
primaquine; chloroquine; mefloquine; fumardiamide; antiproliferative activity
Hrčak ID:
221405
URI
Datum izdavanja:
31.12.2019.
Posjeta: 971 *