Skoči na glavni sadržaj

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, Vol. 559 No. 64-65, 2023.

Izvorni znanstveni članak

https://doi.org/10.21857/94kl4clz3m

Tapping the potential of bone regeneration by delivery of concentrated extracellular vesicles to the fracture site: A new horizon in bone regeneration therapy research?

Lovorka Grgurević orcid id orcid.org/0000-0002-9814-3178 ; Zavod za anatomiju "Drago Perović", Medicinski fakultet Sveučilišta u Zagrebu *
Rudjer Novak orcid id orcid.org/0000-0002-5920-4169 ; Centar za translacijska i klinička istraživanja, Zavod za proteomiku, Medicinski fakultet Sveučilišta u Zagrebu
Stela Hrkač ; Zavod za kliničku imunologiju, alergologiju i reumatologiju, Klinička bolnica Dubrava
Grgur Salai ; Zavod za pulmologiju, Klinička bolnica Dubrava
Jadranka Bubić ; BIMIS - Biomedicinsko istraživačko središte Šalata, Medicinski fakultet Sveučilišta u Zagrebu
Dinko Mitrečić orcid id orcid.org/0000-0003-4836-1721 ; BIMIS - Biomedicinsko istraživačko središte Šalata, Medicinski fakultet Sveučilišta u Zagrebu
Marija Lipar ; Zavod za ortopediju i oftalmologiju, Veterinarski fakultet Sveučilišta u Zagrebu
Tomislav Vlahović ; Klinika za traumatologiju, Klinički bolnički centar "Sestre Milosrdnice"

* Dopisni autor.

Puni tekst: engleski pdf 509 Kb

str. 20-28

preuzimanja: 175

citiraj

Sažetak

Background A small pilot study was conducted in order to investigate in situ regenerative potential of extracellular vesicles (EVs) in a rat subcutaneous implant model.
Material and methods An implant device was implanted in the axillary regions of four animals and consisted of a rat ABC enriched with an EV isolate obtained from human patients 7-21 days post bone fracture, or healthy individuals.
Results Upon histological examination of the implanted devices, there were clear evidence of early signs of immature cartilage and bone formation in the implants of fracture-EV treated animals, 21 days post implantation.
Conclusion These preliminary results suggest a potential for near-term innovation in the development of an affordable, non-invasive and completely autologous therapeutic device that can potentially
enhance the existing regenerative capacity of skeletal tissues. EV can be used to concentrate the body’s inherent regenerative potential and utilise it as a personalised self-healing therapy.

Ključne riječi

extracellular vesicles; regeneration; subcutaneous assay; bone; fracture

Hrčak ID:

312649

URI

https://hrcak.srce.hr/312649

Datum izdavanja:

22.12.2023.

Posjeta: 459 *