Izvorni znanstveni članak

https://doi.org/10.20471/acc.2026.65.01.07

Vascular Calcification Regulated by Klotho During Physiological and Pathophysiological Aging

Davor Primc ; Department of Vascular Surgery, Clinical Hospital Center Rijeka, Rijeka, Croatia
Viktor Peršić ; Special Hospital for Medical Rehabilitation of Heart, Lung and Rheumatic Diseases Thalassotherapia Opatija, Opatija, Croatia
Josip Španjol ; Department of Urology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Dalibor Divković ; Department of Surgery, Urology, Orthopedics and Physical and Rehabilitation Medicine, Faculty of Medicine, University of Osijek, Osijek, Croatia; Department of Surgery, University Hospital Osijek, Osijek, Croatia
Miljenko Kovačević ; Department of Vascular Surgery, Clinical Hospital Center Rijeka, Rijeka, Croatia
Sanja Pećanić ; Department of Vascular Surgery, Clinical Hospital Center Rijeka, Rijeka, Croatia
Silvija Miletić Gršković ; Special Hospital for Medical Rehabilitation of Heart, Lung and Rheumatic Diseases Thalassotherapia Opatija, Opatija, Croatia
Gordana Laškarin ; Special Hospital for Medical Rehabilitation of Heart, Lung and Rheumatic Diseases Thalassotherapia Opatija, Opatija, Croatia; Department of Physiology, Immunology and Pathophysiology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia *

* Dopisni autor.

Sažetak

Purpose: The widely spread membrane and soluble Klotho protein plays a pivotal
role in vascular calcification by orchestrating calcium/phosphate/magnesium
homeostasis mediated by the Klotho/fibroblast growth factor 23 receptor
complex. Our aim was to review new scientific data and discuss the role(s) of
Klotho in vascular calcification.
The basic procedures were to review the literature concerning Klotho and its
mechanisms of action during physiological and pathological aging.
Main findings: A lack of Klotho shortens the lifespan, increases vascular calcification
and the frequency of cardiovascular diseases with multiple organ
degeneration and weakness in experimental animal models. In humans, the
most prominent decrease of Klotho protein and mRNA is found in patients with
chronic kidney disease–mineral and bone disorder (CKD–MBD), which shows
accelerated aging due to increased vascular calcification. Additionally, Klotho
acts in an endocrine manner participating in different signaling pathways as an
anti-inflammatory, antioxidant, anti-fibrotic and anti-aging mediator, preserving
vascular structure and function. Principal conclusions: Klotho is a possible early marker for the detection and monitoring of subclinical arterial calcification in patients with CKD–MBD and in
the general population.

Ključne riječi

α-Klotho; Vascular calcification; Chronic kidney disease–mineral bone disorder; Fibroblast growth factor 23; Hyperphosphatemia

Hrčak ID:

345831

URI

https://hrcak.srce.hr/345831

Datum izdavanja:

27.3.2026.

Podaci na drugim jezicima: hrvatski

Posjeta: 307 *