Stručni rad
Cardiovascular Risk and Systemic Inflammation in Alopecia Areata: An Observational Case-control Study
Alberto Soto-Moreno
; Servicio de Dermatología. Hospital Universitario Virgen de Las Nieves. Granada, Spain
Jose Muñoz-Baeza
; Departamento de Dermatología, Facultad de Medicina, Universidad de Granada, Granada, Spain
Daniel Muñoz-Barba
; Servicio de Dermatología. Hospital Universitario Virgen de Las Nieves. Granada, Spain
Manuel Sánchez-Díaz
; Servicio de Dermatología. Hospital Universitario Virgen de Las Nieves. Granada, Spain
*
Salvador Arias-Santiago
; Servicio de Dermatología. Hospital Universitario Virgen de Las Nieves. Granada, Spain
* Dopisni autor.
Sažetak
Alopecia areata (AA) is an autoimmune disorder characterized
by non-scarring hair loss, often accompanied by systemic manifestations,
suggesting a potential link to systemic inflammation. While
previous studies have explored the association between AA and cardiovascular
risk (CVR), findings remain inconsistent. The main objectives of
the study were to analyze cardiovascular risk (CVR) and systemic inflammatory
activity in patients with AA compared with healthy controls. Additionally,
the study aimed to investigate associations between systemic
inflammation/CVR and baseline clinical variables in patients with AA. The
study used a case-control design with patients matched for age, sex, and
anthropometric characteristics. Measurements of blood pressure, pulse
wave velocity, lipid and carbohydrate metabolism parameters, systemic
inflammatory markers, and vitamin D levels were conducted. Seventytwo
participants were included in the study (36 patients with AA, 36
healthy controls), of whom 72.2% were women (52/72), with a mean age
of 39 years (±2.6). The baseline Severity of Alopecia Tool (SALT) values
in patients with AA was 42% (±6). Patients with AA had higher systolic
blood pressure than controls, with no differences in diastolic blood pressure,
pulse wave velocity, or metabolic profile. Patients with AA showed
higher systemic inflammation parameters and lower vitamin D levels.
No association was observed between CVR and systemic inflammation;
these factors were not associated with disease severity, duration, or type
of treatment. Despite presenting similar cardiovascular risk profiles to
healthy controls, patients with AA demonstrated elevated systemic inflammatory
activity. However, these factors did not appear to be interrelated,
and were not associated with disease severity. risk profiles to
healthy controls, they had elevated systemic inflammatory activity and
lower vitamin D levels
Ključne riječi
alopecia areata; cardiovascular risk; metabolic risk; inflammation
Hrčak ID:
346948
URI
Datum izdavanja:
26.2.2025.
Posjeta: 0 *