Izvorni znanstveni članak

https://doi.org/10.2478/v10007-011-0018-2

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

SWASTIKA GANGULY orcid.org/0000-0001-5042-0773 ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
VATSAL VIJAY VITHLANI ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
ANUP KUMAR KESHARWANI ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
RITU KUHU ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
LAKSHMANAN BASKAR ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
PAPIYA MITRAMAZUMDER ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
ASHOK SHARON ; Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India
ABHIMANYU DEV ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

Sažetak

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylamino-propan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H- imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

Ključne riječi

imidazole; reverse transcriptase; non-nucleoside reverse transcriptase; anti-HIV; antibacterial

Hrčak ID:

66189

URI

https://hrcak.srce.hr/66189

Datum izdavanja:

1.6.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.767 *