Veterinarski arhiv, Vol. 70 No. 2, 2000.
Izvorni znanstveni članak
Clinical experimental studies on acute rumen acidosis in sheep with a pre-existing chronic lead and organophosphorus compound intoxication. I. Clinical and haematological changes.
Yordan Nikolov
; Department of Internal Diseases and Clinical Toxicology, Faculty of Veterinary Medicine, Thrachia University, Stara Zagora, Bulgaria
Sažetak
Experiments were performed on 15 sheep divided into 2 groups (A - 7 animals; B - 8 animals) in order to monitor the changes in clinical and haematological parameters in chronic lead and pesticide intoxication followed by acute rumen acidosis. A chronic lead and Fosdrin 24 intoxication was provoked in both groups via administration of lead acetate at a dose rate of 15 mg/kg body mass and 3.5 mg/kg body mass of organophosphorus insecticide Fosdrin 24 (2-carbomethoxy-1-methylvinyl-dimethylphosphate) once weekly, 2 hours after morning feeding for 6 months. Before treatment of experimental groups with the toxic combination, blood samplings were performed in 15-day intervals, and after the beginning of the experiment on a monthly basis until the end of the 6th month, for determination of haemoglobin, erythrocyte counts, total and differential leukocyte counts, haematocrit values, erythrocyte sedimentation rate. At the end of the 6th month, acute rumen acidosis was provoked in group B sheep via the administration of 20 ml/kg body mass beet molasses containing 540 g/l saccharose. Haematological and clinical parameters were followed out in dynamics at hours 2, 6, 10, 12, 20 post-treatment and compared with group A sheep. It was concluded that the application of the aforementioned doses of xenobiotics resulted in chronic intoxication with clearly expressed clinical and haematological changes: accelerated heart and respiratory rates, erythropenia, oligochromia and leucocytosis. On the basis of the chronic lead and insecticide intoxication, the acute rumen acidosis aggravated the clinical and haematological changes and resulted in total lethality for animals in group B.
Ključne riječi
acute rumen acidosis; sheep; lead chronic intoxication; organophosphorus chronic intoxication
Hrčak ID:
96193
URI
Datum izdavanja:
22.4.2000.
Posjeta: 1.810 *