Izvorni znanstveni članak
A Correlation between the Expression of Estrogen Receptors and Progesterone Receptors in Cancer Cells and in the Myometrium and Prognostic Factors in Endometrial Cancer
Darko Tomica
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia
Damir Danolić
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia
Ilija Alvir
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia
Ivica Mamić
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia
Mario Puljiz
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Gynecologic Oncology, Zagreb, Croatia
Fabijan Knežević
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Clinical Pathology, Zagreb, Croatia
Melita Perić Balja
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Clinical Pathology, Zagreb, Croatia
Snježana Ramić
; University of Zagreb, »Sestre Milosrdnice« University Hospital Centre, University Hospital for Tumors, Department of Clinical Pathology, Zagreb, Croatia
Toni Kolac
; University of Zagreb, Dubrava University Hospital, Department of Surgery, Zagreb, Croatia
Sažetak
Endometrial cancer is the most common gynecological malignancy in Croatia. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PGR) in cancer cells and in the myometrium and to correlate it with prognostic factors of endometrial carcinoma. ER positivity in carcinoma cell nuclei was found in 42 cases (73.7%) and PGR positivity was found in 39 cases (68.4%). Loss of ER in carcinoma cell nuclei correlated with larger tumor size (p=0.041), poor carcinoma differentiation (p=0.012), a more aggressive histological type (p<0.001), lymphovascular space invasion (p=0.002) and a higher surgical stage (p=0.037). Loss of PGR in carcinoma cell nuclei correlated with an increased age in patients (p=0.009), poor tumor differentiation (p=0.002), a more aggressive histological type (p<0.001), lymphovascular space invasion (p=0.002) and a higher surgical stage (p<0.001). The lower expression of both receptors did not correlate with the depth of myometrial invasion. Regarding the status of receptors in the myometrium, loss of PGR in the myometrium correlated with a more aggressive histological type (p=0.005) and a lack of ER in the myometrium tended to correlate with tumor growth (p=0.059). In conclusion, the loss of both hormone receptors in carcinoma cells and loss of PGR in the myometrium was a predictor of a more aggressive type of endometrial cancer and a poor prognosis.
Ključne riječi
endometrial cancer; estrogen receptor; progesterone receptor; myometrium
Hrčak ID:
120806
URI
Datum izdavanja:
31.3.2014.
Posjeta: 1.107 *