Acta Pharmaceutica, Vol. 54 No. 2, 2004.
Izvorni znanstveni članak
Lipophilicity study of salicylamide
MARICA MEDIĆ-SARIĆ
ANA MORNAR
IVONA JASPRICA
Sažetak
Molecular lipophilicity was studied using salicylamide as a model drug. Log P value for the target compound was experimentally determined by the "shake-flask" method and calculated using nine different computer programs based on atom/fragment contributions, structural parameters, atom-type electrotopological-state indices and neural network modeling, and on topological structure descriptors. Our analysis demonstrates good agreement between the experimentally observed log P value of salicylamide and the value calculated by the CSLogP program, based on topological structure descriptors and electrotopological indices.
Ključne riječi
lipophilicity; salicylamide; log P; computer modeling
Hrčak ID:
16795
URI
Datum izdavanja:
1.6.2004.
Posjeta: 2.737 *