Croatica Chemica Acta, Vol. 54 No. 1, 1981.
Izvorni znanstveni članak
Application of 4-Chlorobutyryl Group as Amino Protective Group in the Synthesis of 7-(D-2-Amino-2-phenylacetamido)-3-methyl-3-cephem-4-carboxylic Acid (Cephalexin)
Z. Mandić
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
J. J. Herak
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
M. Tomić
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
B. Vranešić
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
M. Kovačević
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
B. Gašpert
; Research Institute PLIVA, Zagreb, Croatia, Yugoslavia
Sažetak
4-Chlorobutyryl group was used as amino protective group
for n(-)-alpha-phenylglycine (I). N-Hydroxysuccinimide ester III
was prepared in high yield but partly racemic. Reaction of III
or IV with V afforded epimeric mixtures of N,0-protected cephalexins
(VI), which can be separated by crystallisation. The 4-chlorobutyryl
group in VII was removed under very mild conditions
giving cephalexin (IX) in good yield and purity.
Ključne riječi
Hrčak ID:
194437
URI
Datum izdavanja:
15.3.1981.
Posjeta: 780 *