Pregledni rad
Changes in Metabolism of Cortisol after Ischemic Stroke and Myocardial Infarction
Omer Ć. Ibrahimagić
Osman Sinanović
Dževdet Smajlović
Mirjana Vidović
Sažetak
The period following ischemic stroke and myocardial
infarction is marked by numerous metabolic changes.
The aim of the study was to determine morning serum levels of
cortisol in patients with ischemic stroke and myocardial infarction
within 48 hours and 15 days after begining of diseases.
Study group included 40 patients, 20 of them were females,
mean age 65.3±10.3 years. Control group included 30 patients,
11 of theme were females, mean age 57.46±10.6 years.The
patients did not receive any corticosteroid agents or spironolactone,
and did not suffer from Cushing’s or Addison’s syndrome.
The fl uorometric method with DELFIA® Cortisol immunoassay
was used to determine morning serum cortisol levels. Reference
values of the measured hormone were 201-681 nmol/L. The
mean level of serum cortisol within 48 hours of ischemic stroke
was 560.9 ± 318.9 nmol/L, and on day 15 it was 426.2 ± 159.3
nmol/L, i.e. signifi cantly lower (p<0.02). On the fi rst measurement,
the level of serum cortisol was elevated in 32%, and on
the second measurement in only 7.5% patients, which was also
signifi cantly lower (p<0.001). The mean level of serum cortisol
within 48 hours of myocardial infarction was 576.2 ± 228.95,
and on day 15 it was 371.9 ± 136.1 nmol/L, i.e. signifi cantly
lower (p<0.001). On the fi rst measurement, the level of serum
cortisol was elevated in 33.3%, and on the second measurement
in 0% patients, which was also signifi cantly lower (p<
0.001). It was concluded that the cortisol levels in patients with
ischemic stroke and myocardial infarction patient was more
pronounced within the fi rst 48 hours after begining of diseases.
Morning cortisol levels was considerably less pronounced 15
days after ischemic stroke and myocardial infarction.
Ključne riječi
ischemic stroke; myocardial infarction; cortisol
Hrčak ID:
18839
URI
Datum izdavanja:
26.1.2006.
Posjeta: 3.641 *