Medicus, Vol. 27 No. 1 Debljina i ..., 2018.
Pregledni rad
Obesity and Gut Microbiota
Maja Bokan
Goran Hauser
Sažetak
Gut microbiota refers to the entire population of microorganisms that colonize a specific location in the digestive tract. It includes not only bacteria, but also other microbes such as fungi, archaea, viruses and protozoa. Healthy gut microbiota comprises mostly of Phyla firmicutes and bacteroidetes. Gut microbiota and its role in the aetiology of obesity is a new area of research that is trying to explain the excess energy accumulation in obese people. Microbiota can also be a potential target of therapeutic manipulation aimed at reducing energy storage in the host. Several mechanisms have been proposed to explain the role of gut microbiota in the aetiology of obesity, including short-chain fatty acid production, hormone stimulation, chronic low-grade inZammation and specific lipoprotein synthesis. Evidence from animal testing suggests that the use of probiotics could reduce the amount of fat gained as a result of a high-fat diet (HFD). Probiotic supplements with Lactobacillus curvatus HY7601, Lactobacillus plantarum KY1032, Pediococcus pentosaceus LP28 and Lactobacillus rhamnosus GG have reduced adipose tissue accumulation and plasma triglyceride levels and have improved insulin sensitivity. Evidence from animal and human studies indicates controversies in determining the cause and e\ect relationship between gut microbiota and obesity.
Ključne riječi
gut microbiota; obesity; probiotics
Hrčak ID:
199414
URI
Datum izdavanja:
26.4.2018.
Posjeta: 3.323 *