Acta Pharmaceutica, Vol. 58 No. 1, 2008.
Kratko priopćenje
https://doi.org/10.2478/v10007-007-0050-4
Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives
SONIA GEORGE
MANOJ KUMAR PARAMESWARAN
ACHARJEE
RAJA CHAKRABORTY
THENGUNGAL KOCHUPAPPY RAVI
Sažetak
Reaction of ethyl-6-methyl–2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (2a-i). These products on reaction with cyanogen bromide gave 5-(5-amino-1,3,4-oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-one (3a-i). The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-ones (4a-i). These products were characterized by IR, 1H NMR, mass spectra and elemental analysis. Products 4a-i revealed promising antibacterial, antifungal and antioxidant activity.
Ključne riječi
pyrimidinyl oxadiazole amines; pyrimidinone oxadiazolyl indolinones; antibacterial; antifungal; antioxidant
Hrčak ID:
19050
URI
Datum izdavanja:
1.3.2008.
Posjeta: 2.930 *