Medicus, Vol. 10 No. 2_Maligni tumori, 2001.
Pregledni rad
Molecular Genetics - the Future of Oncology
Boris Labar
Sažetak
New insights of molecular mechanisms on
the biology of cancer are reported. The possible mechanism
and disturbance of signaling pathways for cell growth important
for cancer transformation is discussed. Perturbations
and oncogene mutations of signal transduction in cancer disturbance
might be changed by the cell membrane receptor,
intracellular signaling and nuclear transcriptional factors.
Mutation of tumor suppressor genes and deregulation of apoptosis
are also important in cancerogenesis. In the second
part of the text the new molecular techniques important for
diagnosis and prognosis of cancer are described. cDNA microarrays
are a new tool to analyzy gene expression patterns
in human cancer. Molecular classification of tumors into general
categories of gene expression can potentially identify previously
undetected and clinically significant subtypes of cancer.
The first major clinical correlation of gene expression patterns
with disease outcome was documented in diffuse large
B-cell lymphoma. By gene-chip arrays this lymphoma is divided
into two molecularly distinct forms with different survival.
Ključne riječi
oncogenes; tumor supressor genes; apoptosis; gene-chip arrays
Hrčak ID:
19342
URI
Datum izdavanja:
15.11.2001.
Posjeta: 3.732 *