Medicus, Vol. 13 No. 1_Depresija, 2004.
Pregledni rad
Pharmacotherapy of Depressions
Vera Folnegović-Šmalc
Petra Folnegović Grošić
Neven Henigsberg
Oliver Kozumplik
Gordan Makarić
Ninoslav Mimica
Suzana Uzun
Sažetak
This article shows the classification of antidepressants
that is mainly based on their historical development:
from classical (tricylic and tetracyclic) non-selective antidepressants
and monoamine oxidase inhibitors (MAOIs) to
selective serotonin reuptake inhibitors (SSRIs) and antidepressants
with dual action. The theories of neuroplasticity
have been only mentioned since they are not widely used in
pharmacotherapy.
As this text is intended for Croatian physicians, a detailed
description of antidepressants mainly includes the drugs registered
in Croatia. Of course, this neither reflects the authors’
opinion about the efficacy or tolerability of unregistered antidepressants
nor does it mean that they would not like to have
some of these drugs available for their patients.
As far as its practical implementation is concerned, this article
can also serve as a manual of pharmacotherapy for depressed
patients.
The need for individual and rational approach and the following
principles should be considered: the treatment of patients with
mild to moderate depression falls within the responsibility of
general practitioners, while the treatment of patients with serious
depression and suicidality falls within the responsibility of
psychiatrists. Therapeutically resistant patients should be
referred to relevant subspecialists.
The treatment of depression is primarily carried out with antidepressants.
In addition to antidepressants, it is often important
to coadminister sedatives/hypnotics because some time
is needed for antidepressants to start acting in order to avoid
sleepless nights and thus alleviate suffering and increase
patient compliance.
Ključne riječi
antidepressants; classical antidepressants; monoamine oxidase inhibitors (MAOIs); selective serotonin reuptake inhibitors (SSRIs); dual action
Hrčak ID:
19803
URI
Datum izdavanja:
26.1.2004.
Posjeta: 5.263 *