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Acta stomatologica Croatica : International journal of oral sciences and dental medicine, Vol. 53 No. 3, 2019.

Professional paper

https://doi.org/10.15644/asc53/3/9

Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia

Vanja Vučićević Boras ; Department of Oral Medicine School of Dental Medicine University of Zagreb and Department of Oral Diseases University Hospital Centre Zagreb, Zagreb, Croatia
Martin Jurlina ; Department of Otolaryngology, Head and Neck Surgery University Hospital Centre Zagreb, Zagreb, Croatia
Vlaho Brailo ; Department of Oral Medicine School of Dental Medicine University of Zagreb and Department of Oral Diseases University Hospital Centre Zagreb, Zagreb, Croatia
Katarina Đurić Vuković ; Department of Otolaryngology, Head and Neck Surgery University Hospital Centre Zagreb, Zagreb, Croatia
Pavle Rončević ; Department of Haematology University Hospital Centre Zagreb, Zagreb, Croatia
Sandra Bašić Kinda ; Department of Haematology University Hospital Centre Zagreb, Zagreb, Croatia
Danica Vidović Juras ; Department of Oral Medicine School of Dental Medicine University of Zagreb and Department of Oral Diseases University Hospital Centre Zagreb, Zagreb, Croatia
Dragana Gabrić ; Department of Oral Surgery School of Dental Medicine University of Zagreb and Department of Oral Surgery University Hospital Centre Zagreb, Zagreb, Croatia

Full text: croatian pdf 228 Kb

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Full text: english pdf 228 Kb

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Abstract

A 54-year-old male patient with acute lymphoblastic leukemia was referred to the Department of Oral Medicine. He had a primary refractory disease and was treated according to HOVON71 and HAM protocol. Sixteen days after the start of the HAM protocol the patient developed palatal dark red/brownish lesion and maxillary vestibular exophytic lesion. Biopsy specimens from oral lesions were taken and microbiologic evaluation confirmed the presence of Aspergillus fumigatus and Rhizopus genus. The treatment of the patient consisted of the inferior maxillectomy and intravenous posaconazole and amphotericine B for the following 28 days. Since the coinfection with Aspergillus and Rhizopus is extremely rarely seen in the oral cavity, a diagnostic and therapeutic dilemma easily presents itself.

Keywords

Mouth Diseases; Mucormycosis; Aspergillosis; Immunocompromised Host; Leukemia

Hrčak ID:

225689

URI

https://hrcak.srce.hr/225689

Publication date:

26.9.2019.

Article data in other languages: croatian

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