Croatica Chemica Acta, Vol. 23 No. 1-2, 1951.
Izvorni znanstveni članak
Synthesis of the Homologue of L-Leucine (Synthesis of-β-Amino-D-methyl-caproic Acid)
K. Balenović
; Chemical Institute, Faculty of Science, Zagreb, Croatia
D. Brovet-Keglević
; Chemical Institute, Faculty of Science, Zagreb, Croatia
Sažetak
It has been shown that N-Phthalyl-derivatives of a-amino- acids can be converted into the corresponding diazoketones. We have applied this reaction to the preparation of the homologue of L-leucine by the Arndt-Eistert synthesis from the hitherto undescribed diazoketone of N-phthalyl-L-leucine (I), Methanolic solution of (I) heated with silver oxyde yielded the optically active ester of the homologous acid (Il), which, refluxed with hydriodic acid, gave the free, optically active B-amino acid (III).
Ključne riječi
Hrčak ID:
249921
URI
Datum izdavanja:
30.9.1951.
Posjeta: 327 *