Izvorni znanstveni članak

https://doi.org/10.20471/acc.2021.60.02.06

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

Antonija Tadin ; Department of Restorative Dental Medicine and Endodontics, Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia
Lidia Gavić ; Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia
Marija Roguljić ; Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia
Mario Babić ; Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia
Ivan Galić ; Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia
Davor Želježić ; Division for Mutagenesis, Institute for Medical Research and Occupational Health, Zagreb, Croatia

Sažetak

The aim of this cross-sectional study was to investigate the occurrence of chromosomal
abnormalities through the frequency of micronuclei and other genomic damage markers in
patients with chronic generalized periodontitis and without periodontal disease. Micronucleus assay
was performed in exfoliated gingival epithelial cells of 35 patients with generalized chronic periodontitis
and 30 control subjects with healthy periodontium. Full mouth clinical examination was performed
to define periodontal condition. The mean number of cells with micronuclei observed in
chronic periodontitis and control groups was 1.8 (±1.49) and 2.0 (±1.34), respectively. Differences
between the groups were not significant (p=0.574). Compared to control subjects, patients with
chronic periodontitis showed a significant increase in the number of binucleated cells (p≤0.001) and
number of cells with nucleoplasmic bridges (p=0.042). Study results indicated that chronic periodontitis
was not associated with higher occurrence of chromosomal damage in gingival cells compared to
individuals with healthy periodontium.

Ključne riječi

Periodontitis; Cytotoxicity; Genotoxicity; Gingival cell; Micronucleus assay

Hrčak ID:

263336

URI

https://hrcak.srce.hr/263336

Datum izdavanja:

1.6.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 892 *