Acta clinica Croatica, Vol. 60. No. 4., 2021.
Pregledni rad
https://doi.org/10.20471/acc.2021.60.04.21
Modern Approach to Dyspepsia
Barbara Medić
; Zagreb Health Center-Center, Zagreb, Croatia
Žarko Babić
orcid.org/0000-0002-5108-5433
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Division of Interventional Gastroenterology, Dubrava University Hospital, Zagreb, Croatia
Marko Banić
; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; School of Medicine, University of Rijeka, Rijeka, Croatia; Division of Inflammatory Bowel Disease and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia
Lana Ljubičić
; Zagreb Health Center-Center, Zagreb, Croatia
Sažetak
Dyspepsia is a disorder characterized by dyspeptic symptoms which are located in
the epigastrium and related to digestion of food in the initial part of the digestive system. In functional
dyspepsia, unlike organic dyspepsia, there is no underlying organic disease that would cause
dyspeptic symptoms. Immune and mucosal function changes, gastric dysmotility, different composition
of the gastrointestinal microbiota, and altered central nervous system processing are considered
responsible for the onset of the disorder. The diagnosis is based on history, clinical presentation, and
exclusion of other organic diseases of the gastrointestinal tract manifested by dyspeptic symptoms.
Therapy includes eradication of Helicobacter pylori infection, proton pump inhibitors, prokinetics, neuromodulators,
and herbal preparations. Unfortunately, in some patients, this therapy leads to little or
no improvement. The prevalence of functional dyspepsia is increasing. It has become one of the more
common gastroenterological diagnoses. In order to reduce the costs associated with the diagnosis and
treatment of the disorder itself, its mechanisms need to be fully elucidated and thus enable finding
appropriate therapy for all patient subgroups.
Ključne riječi
Dyspepsia; Helicobacter pylori; Hypersensitivity; Visceral pain; Microbiota
Hrčak ID:
275518
URI
Datum izdavanja:
1.12.2021.
Posjeta: 3.056 *