Sažetak sa skupa
https://doi.org/10.26800/LV-145-supl2-BS06
ISOSORBIDE-5-MONONITRATE INDUCED PERIPHERAL AND CENTRAL VASCULAR DYSFUNCTION IN RATS AND TRETMENT WITH STABLE GASTRIC PENTADECAPEPTIDE BPC 157
Vlasta Vuković
; Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Vraneš
Luka Kalogjera
Sažetak
Introduction: Although the understanding of migraine pathophysiology is incomplete, it is now well accepted that this neurovascular syndrome is
mainly due to cranial vasodilation. Several experimental migraine models have been developed, including the use of a nitric oxide (NO) donor, such as isosorbide-5-mononitrate (IS-5-MN). Nitric oxide regulates cerebral and extracerebral cranial blood flow and arterial diameters. We observed the therapeutic effects of stable gastric pentadecapeptide BPC 157 on peripheral and central vascular dysfunction caused by IS-5- MN administration .
Ključne riječi
BPC157; IS-5-MN; migraine; pharmacology; vascular dysfunction
Hrčak ID:
303006
URI
Datum izdavanja:
23.4.2023.
Posjeta: 184 *