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The Efficacy of Cisapride vs. Placebo and Diet in Patients with Chronic Constipation

Karmela Altabas
Ante Bilić
Dragan Jurčić
Zdravko Dorosulić
Mate Mihanović
Martina Šunić-Omejc
Branka Restek-Petrović
Nikolina Tolj


Puni tekst: engleski pdf 78 Kb

str. 197-204

preuzimanja: 681

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Sažetak

The effects of cisapride (10 mg three times daily) on the stool evacuation characteristics,
laxative consumption (symptom diary) and motility pattern (rectoanal manometry)
were assessed in patients with chronic idiopathic constipation who fulfilled Rome II criteria.
After a 14-day basal period on a diet rich in fiber (phase I), patients were treated
with placebo (n=20) or cisapride (n=19) (phase II). Anorectal manometry was performed
at the end of each phase. The study was controlled, randomized and double blind. Side
effects related to the use of cisapride were noted and found to be mild. Cisapride and
placebo increased stool frequency from 4 (1–11) to 7 (14–12) (p<0.001) and from 4 (2–10)
to 6 (2–11) (p<0.05) per week, respectively. Straining was decreased from 69.0% to 39.7%
in the cisapride (p<0.0001) group, and from 79% to 35% (p<0.0001) in the placebo
group. Both cisapride and placebo decreased the feeling of incomplete evacuation from
91.7% to 37.5% (p<0.0001) and from 82.7% to 39.2% (p<0.0001), respectively. Cisapride
reduced the need of laxatives and showed a tendency to normalize stool consistency but
did not influence any other symptom or bowel motility parameter.

Ključne riječi

constipation; cisapride; motility

Hrčak ID:

28065

URI

https://hrcak.srce.hr/28065

Datum izdavanja:

16.6.2003.

Posjeta: 1.358 *

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