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Original scientific paper
https://doi.org/10.5562/cca2198

Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction

Luka Krstulović ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Hamit Ismaili ; Faculty of Mathematics and Natural Sciences, University of Pristina, Agim Ramadani n.n. 10000, Pristina, Kosovo
Miroslav Bajić ; Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Aleksandar Višnjevac ; Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
Ljubica Glavaš-Obrovac ; Department of Clinical Chemistry and Biochemistry, School of Medicine, J. J. Strossmayer University of Osijek, Huttlerova 4, HR-31000 Osijek, Croatia;Clinical Hospital Centre Osijek, Clinical Institute of Nuclear Medicine and Radiation Protection, Huttler
Biserka Žinić   ORCID icon orcid.org/0000-0002-1536-7142 ; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia

Fulltext: english, pdf (2 MB) pages 525-534 downloads: 1.183* cite
APA 6th Edition
Krstulović, L., Ismaili, H., Bajić, M., Višnjevac, A., Glavaš-Obrovac, Lj. & Žinić, B. (2012). Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction. Croatica Chemica Acta, 85 (4), 525-534. https://doi.org/10.5562/cca2198
MLA 8th Edition
Krstulović, Luka, et al. "Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction." Croatica Chemica Acta, vol. 85, no. 4, 2012, pp. 525-534. https://doi.org/10.5562/cca2198. Accessed 26 Sep. 2021.
Chicago 17th Edition
Krstulović, Luka, Hamit Ismaili, Miroslav Bajić, Aleksandar Višnjevac, Ljubica Glavaš-Obrovac and Biserka Žinić. "Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction." Croatica Chemica Acta 85, no. 4 (2012): 525-534. https://doi.org/10.5562/cca2198
Harvard
Krstulović, L., et al. (2012). 'Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction', Croatica Chemica Acta, 85(4), pp. 525-534. https://doi.org/10.5562/cca2198
Vancouver
Krstulović L, Ismaili H, Bajić M, Višnjevac A, Glavaš-Obrovac Lj, Žinić B. Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction. Croatica Chemica Acta [Internet]. 2012 [cited 2021 September 26];85(4):525-534. https://doi.org/10.5562/cca2198
IEEE
L. Krstulović, H. Ismaili, M. Bajić, A. Višnjevac, Lj. Glavaš-Obrovac and B. Žinić, "Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction", Croatica Chemica Acta, vol.85, no. 4, pp. 525-534, 2012. [Online]. https://doi.org/10.5562/cca2198

Abstracts
A series of new aliphatic N-sulfonylamidino thymine derivatives containing nucleobase,
N-sulfonyl and amidine pharmacophores in the structure were synthesized by Cu(I)-catalyzed threecomponent
coupling of 1-propargyl thymine, benzenesulfonyl azides and amines or ammonium salts. Preliminary
in vitro antitumor screening (human cervix adenocarcinoma -HeLa and leukemia cells - Jurkat)
revealed promising activities of N,N-diethyl- (2) and N-4-cyanobenzyl- (6) derivatives of 4-acetamidobenzenesulfonyl
amidine. (doi: 10.5562/cca2198)

Keywords
alkynes; azides; copper; nucleobases; N-sulfonylamidine

Hrčak ID: 94451

URI
https://hrcak.srce.hr/94451

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