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Acta Pharmaceutica, Vol. 63 No. 3, 2013.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2013-0029

Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry

IOAN TOMUŢĂ ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania
DANA DUDAŞ ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania
ANDREEA LOREDANA VONICA ; S.C. Polipharma Industries, 550052, Sibiu, Romania
SORIN E. LEUCUŢA ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania

Puni tekst: engleski, pdf (502 KB) str. 373-384 preuzimanja: 1.740* citiraj
APA 6th Edition
TOMUŢĂ, I., DUDAŞ, D., VONICA, A.L. i LEUCUŢA, S.E. (2013). Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry. Acta Pharmaceutica, 63 (3), 373-384. https://doi.org/10.2478/acph-2013-0029
MLA 8th Edition
TOMUŢĂ, IOAN, et al. "Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry." Acta Pharmaceutica, vol. 63, br. 3, 2013, str. 373-384. https://doi.org/10.2478/acph-2013-0029. Citirano 22.05.2019.
Chicago 17th Edition
TOMUŢĂ, IOAN, DANA DUDAŞ, ANDREEA LOREDANA VONICA i SORIN E. LEUCUŢA. "Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry." Acta Pharmaceutica 63, br. 3 (2013): 373-384. https://doi.org/10.2478/acph-2013-0029
Harvard
TOMUŢĂ, I., et al. (2013). 'Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry', Acta Pharmaceutica, 63(3), str. 373-384. doi: https://doi.org/10.2478/acph-2013-0029
Vancouver
TOMUŢĂ I, DUDAŞ D, VONICA AL, LEUCUŢA SE. Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry. Acta Pharm. [Internet]. 2013 [pristupljeno 22.05.2019.];63(3):373-384. doi: https://doi.org/10.2478/acph-2013-0029
IEEE
I. TOMUŢĂ, D. DUDAŞ, A.L. VONICA i S.E. LEUCUŢA, "Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry", Acta Pharmaceutica, vol.63, br. 3, str. 373-384, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0029

Sažetak
The paper proposes a near infrared methodable to directlyand simultaneously quantify ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets without any sample preparation.In the first step, calibration models for the quantification of ascorbic acid and sodium ascorbate in powder blends for tabletingand subsequently in chewable vitamin C tablets (corresponding to 80–120 % active substance) were developed according to an experimental design with 2 variables and 5 levels. Then, using the best calibration models, the methods were fully validatedin terms of recovery, precision and accuracyfor both powder blends and vitamin Cchewable tablets.The validated concentration range was 15.14–18.51 % for ascorbic acid and 12.06–14.49 % for sodium ascorbate in powder blends and 91.85–111.03 mg per tablet for ascorbic acid and 71.01–84.50 mg per tablet for sodium ascorbate in tablets. Validation results showed good precision and accuracy.

Ključne riječi
NIR spectroscopy; chemometrics; ascorbic acid; sodium ascorbate; validation; powder blends

Hrčak ID: 103921

URI
https://hrcak.srce.hr/103921

Posjeta: 1.965 *