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Arhiv za higijenu rada i toksikologiju, Vol.64 No.2 Lipanj 2013.

Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-64-2013-2319

Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells

Anja Fic ; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
Marija Sollner Dolenc ; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
Metka Filipič ; National Institute of Biology, Department for Genetic Toxicology and Cancer Biology, Ljubljana, Slovenia
Lucija Peterlin Mašić ; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Puni tekst: engleski, pdf (128 KB) str. 189-199 preuzimanja: 1.398* citiraj
APA 6th Edition
Fic, A., Sollner Dolenc, M., Filipič, M. i Peterlin Mašić, L. (2013). Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells. Arhiv za higijenu rada i toksikologiju, 64 (2), 189-199. https://doi.org/10.2478/10004-1254-64-2013-2319
MLA 8th Edition
Fic, Anja, et al. "Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells." Arhiv za higijenu rada i toksikologiju, vol. 64, br. 2, 2013, str. 189-199. https://doi.org/10.2478/10004-1254-64-2013-2319. Citirano 12.11.2018.
Chicago 17th Edition
Fic, Anja, Marija Sollner Dolenc, Metka Filipič i Lucija Peterlin Mašić. "Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells." Arhiv za higijenu rada i toksikologiju 64, br. 2 (2013): 189-199. https://doi.org/10.2478/10004-1254-64-2013-2319
Harvard
Fic, A., et al. (2013). 'Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells', Arhiv za higijenu rada i toksikologiju, 64(2), str. 189-199. doi: https://doi.org/10.2478/10004-1254-64-2013-2319
Vancouver
Fic A, Sollner Dolenc M, Filipič M, Peterlin Mašić L. Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells. Arh Hig Rada Toksikol. [Internet]. 2013 [pristupljeno 12.11.2018.];64(2):189-199. doi: https://doi.org/10.2478/10004-1254-64-2013-2319
IEEE
A. Fic, M. Sollner Dolenc, M. Filipič i L. Peterlin Mašić, "Mutagenicity and DNA Damage of Bisphenol A and Its Structural Analogues in HepG2 Cells", Arhiv za higijenu rada i toksikologiju, vol.64, br. 2, str. 189-199, 2013. [Online]. doi: https://doi.org/10.2478/10004-1254-64-2013-2319

Sažetak
Environmental oestrogen bisphenol A (BPA) and its analogues are widespread in our living environment. Because their production and use are increasing, exposure of humans to bisphenols is becoming a significant issue. We evaluated the mutagenic and genotoxic potential of eight BPA structural analogues (BPF, BPAF, BPZ, BPS, DMBPA, DMBPS, BP-1, and BP-2) using the Ames and comet assay, respectively. None of the tested bisphenols showed a mutagenic effect in Salmonella typhimurium strains TA98 and TA100 in either the presence or absence of external S9-mediated metabolic activation (Aroclor 1254-induced male rat liver). Potential genotoxicity of bisphenols was determined in the human hepatoma cell line (HepG2) at non-cytotoxic concentrations (0.1 μmol L-1 to 10 μmol L-1) after 4-hour and 24-hour exposure. In the comet assay, BPA and its analogue BPS induced signifi cant DNA damage only after the 24-hour exposure, while analogues DMBPS, BP-1, and BP-2 induced a transient increase in DNA strand breaks observed only after the 4-hour exposure. BPF, BPAF, BPZ, and DMBPA did not induce DNA damage.

Ključne riječi
Ames test; bisphenols; comet assay; genotoxicity

Hrčak ID: 103924

URI
https://hrcak.srce.hr/103924

[slovenski]

Posjeta: 1.759 *