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Original scientific paper
https://doi.org/10.2478/10004-1254-64-2013-2248

Melatonin Improves Liver Function in Benzene-treated Rats

Seema Sharma ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
Suresh Vir Singh Rana ; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India

Fulltext: english, pdf (77 KB) pages 219-226 downloads: 612* cite
APA 6th Edition
Sharma, S. & Rana, S.V.S. (2013). Melatonin Improves Liver Function in Benzene-treated Rats. Arhiv za higijenu rada i toksikologiju, 64 (2), 219-226. https://doi.org/10.2478/10004-1254-64-2013-2248
MLA 8th Edition
Sharma, Seema and Suresh Vir Singh Rana. "Melatonin Improves Liver Function in Benzene-treated Rats." Arhiv za higijenu rada i toksikologiju, vol. 64, no. 2, 2013, pp. 219-226. https://doi.org/10.2478/10004-1254-64-2013-2248. Accessed 23 Oct. 2020.
Chicago 17th Edition
Sharma, Seema and Suresh Vir Singh Rana. "Melatonin Improves Liver Function in Benzene-treated Rats." Arhiv za higijenu rada i toksikologiju 64, no. 2 (2013): 219-226. https://doi.org/10.2478/10004-1254-64-2013-2248
Harvard
Sharma, S., and Rana, S.V.S. (2013). 'Melatonin Improves Liver Function in Benzene-treated Rats', Arhiv za higijenu rada i toksikologiju, 64(2), pp. 219-226. https://doi.org/10.2478/10004-1254-64-2013-2248
Vancouver
Sharma S, Rana SVS. Melatonin Improves Liver Function in Benzene-treated Rats. Arh Hig Rada Toksikol. [Internet]. 2013 [cited 2020 October 23];64(2):219-226. https://doi.org/10.2478/10004-1254-64-2013-2248
IEEE
S. Sharma and S.V.S. Rana, "Melatonin Improves Liver Function in Benzene-treated Rats", Arhiv za higijenu rada i toksikologiju, vol.64, no. 2, pp. 219-226, 2013. [Online]. https://doi.org/10.2478/10004-1254-64-2013-2248

Abstracts
In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzenetreated rats thanks to its antioxidative properties.

Keywords
alkaline phosphatase; antioxidants; bilirubin; hydroxyproline; serum transaminases

Hrčak ID: 103928

URI
https://hrcak.srce.hr/103928

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