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Stručni rad
https://doi.org/10.5599/admet.1.3.9

What ADME tests should be conducted for preclinical studies?

Hong Wan ; Shanghai Hengrui Pharmaceutical CO., LTD.

Puni tekst: engleski, pdf (396 KB) str. 19-28 preuzimanja: 26.849* citiraj
APA 6th Edition
Wan, H. (2013). What ADME tests should be conducted for preclinical studies?. ADMET and DMPK, 1 (3), 19-28. https://doi.org/10.5599/admet.1.3.9
MLA 8th Edition
Wan, Hong. "What ADME tests should be conducted for preclinical studies?." ADMET and DMPK, vol. 1, br. 3, 2013, str. 19-28. https://doi.org/10.5599/admet.1.3.9. Citirano 28.10.2021.
Chicago 17th Edition
Wan, Hong. "What ADME tests should be conducted for preclinical studies?." ADMET and DMPK 1, br. 3 (2013): 19-28. https://doi.org/10.5599/admet.1.3.9
Harvard
Wan, H. (2013). 'What ADME tests should be conducted for preclinical studies?', ADMET and DMPK, 1(3), str. 19-28. https://doi.org/10.5599/admet.1.3.9
Vancouver
Wan H. What ADME tests should be conducted for preclinical studies?. ADMET and DMPK [Internet]. 2013 [pristupljeno 28.10.2021.];1(3):19-28. https://doi.org/10.5599/admet.1.3.9
IEEE
H. Wan, "What ADME tests should be conducted for preclinical studies?", ADMET and DMPK, vol.1, br. 3, str. 19-28, 2013. [Online]. https://doi.org/10.5599/admet.1.3.9

Sažetak
The pharmaceutical industry has been evolving in recent years, which made numerous CROs and biotech companies conducting drug discovery and development programs and services in China. As a very comprehensive and important technology platform bridging efficacy and safety, the DMPK has become a mature discovery function to optimise ADME properties in drug design and screening, and dramatically mitgate attrition rates during the last decades. In this article, the author addresses several frequent questions associated with ADME/DMPK studies, e.g., what ADME tests should be conducted for preclinical studies? What should a typical investigational new drug (IND) enabling package cover? Which ADME/DMPK studies require good laboratory practice (GLP) or non-GLP? What does a good PK profile look like? The author presents a straightforward overview of these basic questions from his many years’ experience in both pharmaceutical research and CRO in supporting drug discovery projects and IND filing.

Ključne riječi
DMPK; PK; toxicity; safety; screening cascade; metabolite; drug-drug interaction; investigational new drug

Hrčak ID: 112504

URI
https://hrcak.srce.hr/112504

Posjeta: 27.408 *