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Glucocorticoid induced osteoporosis

Branimir Anić ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine of the School of Medicine, University of Zagreb, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Miroslav Mayer ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine of the School of Medicine, University of Zagreb, Clinical Hospital Centre Zagreb, Zagreb, Croatia

Puni tekst: hrvatski, pdf (490 KB) str. 105-112 preuzimanja: 285* citiraj
APA 6th Edition
Anić, B. i Mayer, M. (2014). Glukokortikoidima izazvana osteoporoza. Reumatizam, 61 (2), 105-112. Preuzeto s https://hrcak.srce.hr/137907
MLA 8th Edition
Anić, Branimir i Miroslav Mayer. "Glukokortikoidima izazvana osteoporoza." Reumatizam, vol. 61, br. 2, 2014, str. 105-112. https://hrcak.srce.hr/137907. Citirano 30.11.2020.
Chicago 17th Edition
Anić, Branimir i Miroslav Mayer. "Glukokortikoidima izazvana osteoporoza." Reumatizam 61, br. 2 (2014): 105-112. https://hrcak.srce.hr/137907
Harvard
Anić, B., i Mayer, M. (2014). 'Glukokortikoidima izazvana osteoporoza', Reumatizam, 61(2), str. 105-112. Preuzeto s: https://hrcak.srce.hr/137907 (Datum pristupa: 30.11.2020.)
Vancouver
Anić B, Mayer M. Glukokortikoidima izazvana osteoporoza. Reumatizam [Internet]. 2014 [pristupljeno 30.11.2020.];61(2):105-112. Dostupno na: https://hrcak.srce.hr/137907
IEEE
B. Anić i M. Mayer, "Glukokortikoidima izazvana osteoporoza", Reumatizam, vol.61, br. 2, str. 105-112, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/137907. [Citirano: 30.11.2020.]

Sažetak
Secondary osteoporosis most often develops due to glucocorticoid therapy. Glucocorticoids affect all stages of the bone remodeling cycle, its formation and resorption. Osteoblasts are primarily affected, decreasing their activity and enhancing apoptosis. Patients treated with glucocorticoids have lower bone mineral density and increased fracture risk. Glucocorticoid-induced osteoporosis can be prevented by administering the minimal effective dose of glucocorticoids, calcium and vitamin D supplementation or, if possible, by hormone replacement therapy. Moreover, appropriate physical activity should be encouraged. Patients who are at higher risk for low-energy fractures (for example post-menopausal women) have to be actively treated, usually with antiresorptive drugs among which bisphosphonates are currently the first line therapy.

Ključne riječi
osteoporosis; glucocorticoids; diagnostics; prevention; treatment

Hrčak ID: 137907

URI
https://hrcak.srce.hr/137907

[hrvatski]

Posjeta: 532 *