hrcak mascot   Srce   HID

Original scientific paper
https://doi.org/10.2478/v10007-007-0026-4

Osjetljiva spektrofotometrijska metoda za određivanje sulfonamida u farmaceutskim pripravcima

PADMARAJAIAH NAGARAJA
SHAILENDRA D. NAIK
ASHWINEE KUMAR SHRESTHA
ANANTHARAMAN SHIVAKUMAR

Fulltext: english, pdf (83 KB) pages 333-342 downloads: 5.106* cite
APA 6th Edition
NAGARAJA, P., NAIK, S.D., SHRESTHA, A.K. & SHIVAKUMAR, A. (2007). A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharmaceutica, 57 (3), 333-342. https://doi.org/10.2478/v10007-007-0026-4
MLA 8th Edition
NAGARAJA, PADMARAJAIAH, et al. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica, vol. 57, no. 3, 2007, pp. 333-342. https://doi.org/10.2478/v10007-007-0026-4. Accessed 5 Aug. 2020.
Chicago 17th Edition
NAGARAJA, PADMARAJAIAH, SHAILENDRA D. NAIK, ASHWINEE KUMAR SHRESTHA and ANANTHARAMAN SHIVAKUMAR. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica 57, no. 3 (2007): 333-342. https://doi.org/10.2478/v10007-007-0026-4
Harvard
NAGARAJA, P., et al. (2007). 'A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations', Acta Pharmaceutica, 57(3), pp. 333-342. https://doi.org/10.2478/v10007-007-0026-4
Vancouver
NAGARAJA P, NAIK SD, SHRESTHA AK, SHIVAKUMAR A. A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharm. [Internet]. 2007 [cited 2020 August 05];57(3):333-342. https://doi.org/10.2478/v10007-007-0026-4
IEEE
P. NAGARAJA, S.D. NAIK, A.K. SHRESTHA and A. SHIVAKUMAR, "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations", Acta Pharmaceutica, vol.57, no. 3, pp. 333-342, 2007. [Online]. https://doi.org/10.2478/v10007-007-0026-4

Abstracts
U radu je opisana nova, jednostavna i osjetljiva spektrofotometrijska metoda za određivanje sulfonamida. Metoda se temelji na prevođenju sulfacetamida, sulfadiazina, sulfagvanidina, sulfamerazina, sulfometazina i sulfametoksazola u diazoderivate koji kondenzacijom s 8-hidroksikinolinom u alkalnom mediju daju crveno obojene produkte s maksimumom apsorpcije pri 500 nm. Beerov zakon vrijedi u koncentracijskom rasponu 0,17,0 µg mL1. Granice kvantifikacije i granice detekcije su 0,11-0,18, odnosno 0,03-0,05 µg mL-1. Za predloženu metodu procijenjene su intermedirska preciznost (RSD 0.1-0,5%) i točnost (analitički povrat 97,3-100,8). Uobičanjene pomoćne tvari u tabletama ne interferiraju tijekom određivanja. Metoda je uspješno primijenjena za analizu sulfonamida u farmaceutskim pripravcima.

Keywords
sulfonamidi; diazotacija; 8-hidroksikinolin; spektrofotometrija; farmaceutski pripravak

Hrčak ID: 13274

URI
https://hrcak.srce.hr/13274

[english]

Visits: 5.680 *