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Acta Pharmaceutica, Vol. 57 No. 3, 2007

Original scientific paper
https://doi.org/10.2478/v10007-007-0026-4

Osjetljiva spektrofotometrijska metoda za određivanje sulfonamida u farmaceutskim pripravcima

PADMARAJAIAH NAGARAJA
SHAILENDRA D. NAIK
ASHWINEE KUMAR SHRESTHA
ANANTHARAMAN SHIVAKUMAR

Fulltext: english, pdf (83 KB) pages 333-342 downloads: 4.590* cite
APA 6th Edition
NAGARAJA, P., NAIK, S.D., SHRESTHA, A.K. & SHIVAKUMAR, A. (2007). A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharmaceutica, 57 (3), 333-342. https://doi.org/10.2478/v10007-007-0026-4
MLA 8th Edition
NAGARAJA, PADMARAJAIAH, et al. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica, vol. 57, no. 3, 2007, pp. 333-342. https://doi.org/10.2478/v10007-007-0026-4. Accessed 24 Mar. 2019.
Chicago 17th Edition
NAGARAJA, PADMARAJAIAH, SHAILENDRA D. NAIK, ASHWINEE KUMAR SHRESTHA and ANANTHARAMAN SHIVAKUMAR. "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations." Acta Pharmaceutica 57, no. 3 (2007): 333-342. https://doi.org/10.2478/v10007-007-0026-4
Harvard
NAGARAJA, P., et al. (2007). 'A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations', Acta Pharmaceutica, 57(3), pp. 333-342. doi: https://doi.org/10.2478/v10007-007-0026-4
Vancouver
NAGARAJA P, NAIK SD, SHRESTHA AK, SHIVAKUMAR A. A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharm. [Internet]. 2007 [cited 2019 March 24];57(3):333-342. doi: https://doi.org/10.2478/v10007-007-0026-4
IEEE
P. NAGARAJA, S.D. NAIK, A.K. SHRESTHA and A. SHIVAKUMAR, "A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations", Acta Pharmaceutica, vol.57, no. 3, pp. 333-342, 2007. [Online]. doi: https://doi.org/10.2478/v10007-007-0026-4

Abstracts
U radu je opisana nova, jednostavna i osjetljiva spektrofotometrijska metoda za određivanje sulfonamida. Metoda se temelji na prevođenju sulfacetamida, sulfadiazina, sulfagvanidina, sulfamerazina, sulfometazina i sulfametoksazola u diazoderivate koji kondenzacijom s 8-hidroksikinolinom u alkalnom mediju daju crveno obojene produkte s maksimumom apsorpcije pri 500 nm. Beerov zakon vrijedi u koncentracijskom rasponu 0,17,0 µg mL1. Granice kvantifikacije i granice detekcije su 0,11-0,18, odnosno 0,03-0,05 µg mL-1. Za predloženu metodu procijenjene su intermedirska preciznost (RSD 0.1-0,5%) i točnost (analitički povrat 97,3-100,8). Uobičanjene pomoćne tvari u tabletama ne interferiraju tijekom određivanja. Metoda je uspješno primijenjena za analizu sulfonamida u farmaceutskim pripravcima.

Keywords
sulfonamidi; diazotacija; 8-hidroksikinolin; spektrofotometrija; farmaceutski pripravak

Hrčak ID: 13274

URI
https://hrcak.srce.hr/13274

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