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Original scientific paper
https://doi.org/10.1515/acph-2016-0021

Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

DONG-GI LEE ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
IK SOON JANG ; Drug & Disease Target Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
KYEONG EUN YANG ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
SO-JUNG YOON ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
SUJEONG BAEK ; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
JOO YONG LEE ; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
TATSURO SUZUKI ; National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido 0820081, Japan
KEUN-YOOK CHUNG ; Department of Agricultural Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea
SUN-HEE WOO ; Department of Crop Science, Chungbuk National University, Cheongju 28644, Republic of Korea
JONG-SOON CHOI ; Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea

Fulltext: english, pdf (571 KB) pages 297-302 downloads: 265* cite
APA 6th Edition
LEE, D., JANG, I.S., YANG, K.E., YOON, S., BAEK, S., LEE, J.Y., ... CHOI, J. (2016). Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes. Acta Pharmaceutica, 66 (2), 297-302. https://doi.org/10.1515/acph-2016-0021
MLA 8th Edition
LEE, DONG-GI, et al. "Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes." Acta Pharmaceutica, vol. 66, no. 2, 2016, pp. 297-302. https://doi.org/10.1515/acph-2016-0021. Accessed 24 Jul. 2019.
Chicago 17th Edition
LEE, DONG-GI, IK SOON JANG, KYEONG EUN YANG, SO-JUNG YOON, SUJEONG BAEK, JOO YONG LEE, TATSURO SUZUKI, KEUN-YOOK CHUNG, SUN-HEE WOO and JONG-SOON CHOI. "Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes." Acta Pharmaceutica 66, no. 2 (2016): 297-302. https://doi.org/10.1515/acph-2016-0021
Harvard
LEE, D., et al. (2016). 'Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes', Acta Pharmaceutica, 66(2), pp. 297-302. https://doi.org/10.1515/acph-2016-0021
Vancouver
LEE D, JANG IS, YANG KE, YOON S, BAEK S, LEE JY, et al. Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes. Acta Pharm. [Internet]. 2016 [cited 2019 July 24];66(2):297-302. https://doi.org/10.1515/acph-2016-0021
IEEE
D. LEE, et al., "Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes", Acta Pharmaceutica, vol.66, no. 2, pp. 297-302, 2016. [Online]. https://doi.org/10.1515/acph-2016-0021

Abstracts
This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.

Keywords
tartary buckwheat sprout; rutin; type 2 diabetes; insulin signaling

Hrčak ID: 153874

URI
https://hrcak.srce.hr/153874

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