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Acta clinica Croatica, Vol. 54. No. 4., 2015.

Stručni rad

Metabolic acidosis - an underestimated problem after kidney transplantation?

Lea Katalinić ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia
Kristina Blaslov ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia
Ana Đanić-Hadžibegović ; School of Medicine, University of Osijek, Osijek, Croatia
Lana Gellineo ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia
Petar Kes ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Bojan Jelaković ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Nikolina Bašić-Jukić   ORCID icon orcid.org/0000-0002-0221-2758 ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Osijek, Osijek, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (133 KB) str. 486-490 preuzimanja: 341* citiraj
APA 6th Edition
Katalinić, L., Blaslov, K., Đanić-Hadžibegović, A., Gellineo, L., Kes, P., Jelaković, B. i Bašić-Jukić, N. (2015). Metabolic acidosis - an underestimated problem after kidney transplantation?. Acta clinica Croatica, 54. (4.), 486-490. Preuzeto s https://hrcak.srce.hr/155463
MLA 8th Edition
Katalinić, Lea, et al. "Metabolic acidosis - an underestimated problem after kidney transplantation?." Acta clinica Croatica, vol. 54., br. 4., 2015, str. 486-490. https://hrcak.srce.hr/155463. Citirano 17.02.2019.
Chicago 17th Edition
Katalinić, Lea, Kristina Blaslov, Ana Đanić-Hadžibegović, Lana Gellineo, Petar Kes, Bojan Jelaković i Nikolina Bašić-Jukić. "Metabolic acidosis - an underestimated problem after kidney transplantation?." Acta clinica Croatica 54., br. 4. (2015): 486-490. https://hrcak.srce.hr/155463
Harvard
Katalinić, L., et al. (2015). 'Metabolic acidosis - an underestimated problem after kidney transplantation?', Acta clinica Croatica, 54.(4.), str. 486-490. Preuzeto s: https://hrcak.srce.hr/155463 (Datum pristupa: 17.02.2019.)
Vancouver
Katalinić L, Blaslov K, Đanić-Hadžibegović A, Gellineo L, Kes P, Jelaković B i sur. Metabolic acidosis - an underestimated problem after kidney transplantation?. Acta clinica Croatica [Internet]. 2015 [pristupljeno 17.02.2019.];54.(4.):486-490. Dostupno na: https://hrcak.srce.hr/155463
IEEE
L. Katalinić, et al., "Metabolic acidosis - an underestimated problem after kidney transplantation?", Acta clinica Croatica, vol.54., br. 4., str. 486-490, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/155463. [Citirano: 17.02.2019.]

Sažetak
Despite prolonged survival and better quality of life as compared to dialysis, kidney transplantation frequently presents with a complex set of medical issues that require intensive management to protect graft function. Metabolic acidosis has an impact on several metabolic complications such as mineral and muscle metabolism, nutritional status and anemia. It may also have an effect on graft function, possibly through the stimulation of adaptive mechanisms aimed at maintaining acid-base homeostasis. We investigated current practice in the evaluation of metabolic acidosis at one of the largest transplant centers in the Eurotransplant region. Adult renal transplant recipients having received allograft from January 2011 to August 2012 were included in the investigation. We recorded the frequency of measuring the parameters of venous blood gas analysis, as well as creatinine and urea levels, creatinine clearance, proteinuria, calcium, phosphate and potassium blood levels, body mass index and the time spent on dialysis prior to kidney transplantation. Out of 203 patients who had received renal allograft at our institution during the observed period, 191 (124 males and 67 females, age range from 18 to 77 years) were enrolled in the study. Of these, only 92 (48.167%) patients had parameters of venous blood gas analysis measured at some time after kidney transplantation. Acid-base status was determined more often in males (77 males vs. 22 females, p=0.001). Patients with pH/blood gas analysis performed were found to have significantly higher creatinine and urea levels and significantly lower creatinine clearance (p<0.001 both). Serum calcium levels were also significantly lower in this group of patients (p<0.001). Metabolic acidosis is a very important clinical issue that needs to be monitored in every transplant recipient. Its effects on graft function, nutritional status, anemia and bone mass are complex but can be successfully managed. Our study showed metabolic acidosis to be linked with significantly higher creatinine and urea levels, decreased creatinine clearance and lower calcium levels. Nevertheless, metabolic acidosis still stays a highly underestimated problem among nephrologists dealing with transplant recipients. We suggest regular determination of the acid-base status in renal transplant recipients.

Ključne riječi
Acidosis; Kidney transplantation; Treatment outcome

Hrčak ID: 155463

URI
https://hrcak.srce.hr/155463

[hrvatski]

Posjeta: 517 *