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Original scientific paper
Utjecaj lindana na metabolizam testosterona u neuroendokrinim organima štakora
B. Šimić
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
J. Kniewald
; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
| Fulltext: english, pdf (5 MB) | pages 11-16 | cite | |
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APA 6th Edition Šimić, B. & Kniewald, J. (1985). Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat. Arhiv za higijenu rada i toksikologiju, 36 (1), 11-16. Retrieved from https://hrcak.srce.hr/156832 MLA 8th Edition Šimić, B. and J. Kniewald. "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat." Arhiv za higijenu rada i toksikologiju, vol. 36, no. 1, 1985, pp. 11-16. https://hrcak.srce.hr/156832. Accessed 27 Feb. 2020. Chicago 17th Edition Šimić, B. and J. Kniewald. "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat." Arhiv za higijenu rada i toksikologiju 36, no. 1 (1985): 11-16. https://hrcak.srce.hr/156832 Harvard Šimić, B., and Kniewald, J. (1985). 'Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat', Arhiv za higijenu rada i toksikologiju, 36(1), pp. 11-16. Available at: https://hrcak.srce.hr/156832 (Accessed 27 February 2020) Vancouver Šimić B, Kniewald J. Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat. Arh Hig Rada Toksikol. [Internet]. 1985 [cited 2020 February 27];36(1):11-16. Available from: https://hrcak.srce.hr/156832 IEEE B. Šimić and J. Kniewald, "Effects of lindane on testosterone metabolism in neuroendocrine organs of male rat", Arhiv za higijenu rada i toksikologiju, vol.36, no. 1, pp. 11-16, 1985. [Online]. Available: https://hrcak.srce.hr/156832. [Accessed: 27 February 2020] |
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Abstracts
Djelovanje lindana na aktivnost enzimskih sistema (5α-R, 3α- and 17β-HSD) uključenih u metabolizam testosterona na nivou hipotalamusa i hipofize mužjaka štakora, proučavana je u in vitro pokusima. U hipofizi lindan inhibira aktivnost 5α-R do 48%, aktivnost 3α-HSD do 41% i 17β-HSD do 29%. Na nivou hipotalamusa lindan inhibira 39% aktivnosti 5α-R, dok aktivnosti 3α- i 17β-HSD nisu bile promijenjene. Mogućnost da lindan inhibira enzimske aktivnosti uključene u metabolizam testosterona u neuroendokrinim organima (hipotalamus i hipofiza), pokazuje da prisutnost tog pesticida u organizmu može uzrokovati promjene u biokemijskim procesima odgovornim za proces reprodukcije.
Hrčak ID: 156832
URI
https://hrcak.srce.hr/156832
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