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CLINICAL AND ETIOPATHOGENETIC ROLE OF PLASMINOGEN AND METOPROTEINASE SYSTEMS IN THE TUMOR GROWTH Pericellular proteolysis of extracellular matrix and tumor growth

Sanda Jelisavac Ćosić
Zdenko Kovač

Puni tekst: hrvatski, pdf (593 KB) str. 0-0 preuzimanja: 62* citiraj
APA 6th Edition
Jelisavac Ćosić, S. i Kovač, Z. (2011). KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast. Liječnički vjesnik, 133 (1-2), 0-0. Preuzeto s https://hrcak.srce.hr/171655
MLA 8th Edition
Jelisavac Ćosić, Sanda i Zdenko Kovač. "KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast." Liječnički vjesnik, vol. 133, br. 1-2, 2011, str. 0-0. https://hrcak.srce.hr/171655. Citirano 20.10.2019.
Chicago 17th Edition
Jelisavac Ćosić, Sanda i Zdenko Kovač. "KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast." Liječnički vjesnik 133, br. 1-2 (2011): 0-0. https://hrcak.srce.hr/171655
Harvard
Jelisavac Ćosić, S., i Kovač, Z. (2011). 'KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast', Liječnički vjesnik, 133(1-2), str. 0-0. Preuzeto s: https://hrcak.srce.hr/171655 (Datum pristupa: 20.10.2019.)
Vancouver
Jelisavac Ćosić S, Kovač Z. KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast. Liječnički vjesnik [Internet]. 2011 [pristupljeno 20.10.2019.];133(1-2):0-0. Dostupno na: https://hrcak.srce.hr/171655
IEEE
S. Jelisavac Ćosić i Z. Kovač, "KLINIČKA I ETIOPATOGENETSKA ULOGA PLAZMINOGENSKOGA I METALOPROTEINAZNOGA SUSTAVA U TUMORSKOME RASTU Pericelularna razgradnja međustaničnoga matriksa i tumorski rast", Liječnički vjesnik, vol.133, br. 1-2, str. 0-0, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/171655. [Citirano: 20.10.2019.]

Sažetak
Pericellular proteolysis is a cascade process involved in degradation of extracellular matrix. This process is included in various physiological and pathological processes. Pericellullar proteolysis has major functions like degradation of tissue stroma and weakening of intercellular connections but it also has a function in the synthesis of bioactive molecules (cytokines, growth factors and inhibitory factors). Plasminogen system is involved in fibrinolysis and starts metalloproteinase activation. Activity of proteolytic molecules is controlled by the rate of zymogenic activation, half-life of molecules, and action of inhibitory molecules. Inhibition is achieved through direct binding of inhibitor and enzyme and takes a few steps. Pericellular proteolysis is involved in tumor invasion and metastasis, inflammatory reaction, degenerative diseases and other diseases. Pathophysiological regulation of pericellular proteolysis in mentioned diseases contributes to clinical properties of diseases and has diagnostic and therapeutic importance.

Ključne riječi
Neoplasms – metabolism, pathology; Neoplasm metastasis – physiopathology; Extracellular matrix – meta bolism; Matrix metalloproteinases – metabolism; Tissue plasminogen activator – metabolism; Urokinase-type plasminogen activator – metabolism, analysis; Plasminogen activator inhibitor 1 – metabolism, analysis; Tumor markers, biological – analysis; Breast neoplasms – diagnosis, pathology

Hrčak ID: 171655

URI
https://hrcak.srce.hr/171655

[hrvatski]

Posjeta: 103 *