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Acta Pharmaceutica, Vol. 55 No. 2, 2005.

Izvorni znanstveni članak

Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates

MARIJANA ZOVKO
MONIKA BARBARIC
BRANKA ZORC
ANITA HAFNER
JELENA FILIPOVIC-GRCIC

Puni tekst: engleski, pdf (125 KB) str. 169-176 preuzimanja: 1.214* citiraj
APA 6th Edition
ZOVKO, M., BARBARIC, M., ZORC, B., HAFNER, A. i FILIPOVIC-GRCIC, J. (2005). Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharmaceutica, 55 (2), 169-176. Preuzeto s https://hrcak.srce.hr/16754
MLA 8th Edition
ZOVKO, MARIJANA, et al. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica, vol. 55, br. 2, 2005, str. 169-176. https://hrcak.srce.hr/16754. Citirano 20.02.2019.
Chicago 17th Edition
ZOVKO, MARIJANA, MONIKA BARBARIC, BRANKA ZORC, ANITA HAFNER i JELENA FILIPOVIC-GRCIC. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica 55, br. 2 (2005): 169-176. https://hrcak.srce.hr/16754
Harvard
ZOVKO, M., et al. (2005). 'Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates', Acta Pharmaceutica, 55(2), str. 169-176. Preuzeto s: https://hrcak.srce.hr/16754 (Datum pristupa: 20.02.2019.)
Vancouver
ZOVKO M, BARBARIC M, ZORC B, HAFNER A, FILIPOVIC-GRCIC J. Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharm. [Internet]. 2005 [pristupljeno 20.02.2019.];55(2):169-176. Dostupno na: https://hrcak.srce.hr/16754
IEEE
M. ZOVKO, M. BARBARIC, B. ZORC, A. HAFNER i J. FILIPOVIC-GRCIC, "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates", Acta Pharmaceutica, vol.55, br. 2, str. 169-176, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/16754. [Citirano: 20.02.2019.]

Sažetak
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.

Ključne riječi
fenoprofen; gemfibrozil; polymer-drug conjugate; macromolecular prodrug; styrene-maleic acid anhydride copolymer

Hrčak ID: 16754

URI
https://hrcak.srce.hr/16754

[hrvatski]

Posjeta: 1.786 *