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Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
MARIJANA ZOVKO
MONIKA BARBARIC
BRANKA ZORC
ANITA HAFNER
JELENA FILIPOVIC-GRCIC
Puni tekst: engleski, pdf (125 KB)
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str. 169-176 |
preuzimanja: 1.214* |
citiraj |
APA 6th Edition ZOVKO, M., BARBARIC, M., ZORC, B., HAFNER, A. i FILIPOVIC-GRCIC, J. (2005). Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharmaceutica, 55 (2), 169-176. Preuzeto s https://hrcak.srce.hr/16754
MLA 8th Edition ZOVKO, MARIJANA, et al. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica, vol. 55, br. 2, 2005, str. 169-176. https://hrcak.srce.hr/16754. Citirano 20.02.2019.
Chicago 17th Edition ZOVKO, MARIJANA, MONIKA BARBARIC, BRANKA ZORC, ANITA HAFNER i JELENA FILIPOVIC-GRCIC. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica 55, br. 2 (2005): 169-176. https://hrcak.srce.hr/16754
Harvard ZOVKO, M., et al. (2005). 'Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates', Acta Pharmaceutica, 55(2), str. 169-176. Preuzeto s: https://hrcak.srce.hr/16754 (Datum pristupa: 20.02.2019.)
Vancouver ZOVKO M, BARBARIC M, ZORC B, HAFNER A, FILIPOVIC-GRCIC J. Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharm. [Internet]. 2005 [pristupljeno 20.02.2019.];55(2):169-176. Dostupno na: https://hrcak.srce.hr/16754
IEEE M. ZOVKO, M. BARBARIC, B. ZORC, A. HAFNER i J. FILIPOVIC-GRCIC, "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates", Acta Pharmaceutica, vol.55, br. 2, str. 169-176, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/16754. [Citirano: 20.02.2019.]
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Sažetak Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.
Ključne riječi fenoprofen; gemfibrozil; polymer-drug conjugate; macromolecular prodrug; styrene-maleic acid anhydride copolymer
Hrčak ID: 16754
URI https://hrcak.srce.hr/16754
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