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Original scientific paper

Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates

MARIJANA ZOVKO
MONIKA BARBARIC
BRANKA ZORC
ANITA HAFNER
JELENA FILIPOVIC-GRCIC

Fulltext: english, pdf (125 KB) pages 169-176 downloads: 1.241* cite
APA 6th Edition
ZOVKO, M., BARBARIC, M., ZORC, B., HAFNER, A. & FILIPOVIC-GRCIC, J. (2005). Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharmaceutica, 55 (2), 169-176. Retrieved from https://hrcak.srce.hr/16754
MLA 8th Edition
ZOVKO, MARIJANA, et al. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica, vol. 55, no. 2, 2005, pp. 169-176. https://hrcak.srce.hr/16754. Accessed 23 Jul. 2019.
Chicago 17th Edition
ZOVKO, MARIJANA, MONIKA BARBARIC, BRANKA ZORC, ANITA HAFNER and JELENA FILIPOVIC-GRCIC. "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates." Acta Pharmaceutica 55, no. 2 (2005): 169-176. https://hrcak.srce.hr/16754
Harvard
ZOVKO, M., et al. (2005). 'Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates', Acta Pharmaceutica, 55(2), pp. 169-176. Available at: https://hrcak.srce.hr/16754 (Accessed 23 July 2019)
Vancouver
ZOVKO M, BARBARIC M, ZORC B, HAFNER A, FILIPOVIC-GRCIC J. Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates. Acta Pharm. [Internet]. 2005 [cited 2019 July 23];55(2):169-176. Available from: https://hrcak.srce.hr/16754
IEEE
M. ZOVKO, M. BARBARIC, B. ZORC, A. HAFNER and J. FILIPOVIC-GRCIC, "Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates", Acta Pharmaceutica, vol.55, no. 2, pp. 169-176, 2005. [Online]. Available: https://hrcak.srce.hr/16754. [Accessed: 23 July 2019]

Abstracts
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.

Keywords
fenoprofen; gemfibrozil; polymer-drug conjugate; macromolecular prodrug; styrene-maleic acid anhydride copolymer

Hrčak ID: 16754

URI
https://hrcak.srce.hr/16754

[croatian]

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