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Acta Pharmaceutica, Vol. 55 No. 2, 2005.

Izvorni znanstveni članak

Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents

YOLIMA BAENA
JORGE A. PINZÓN
HELBER J. BARBOSA
FLMING MARTÍNEZ

Puni tekst: engleski, pdf (94 KB) str. 195-205 preuzimanja: 729* citiraj
APA 6th Edition
BAENA, Y., PINZÓN, J.A., BARBOSA, H.J. i MARTÍNEZ, F. (2005). Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents. Acta Pharmaceutica, 55 (2), 195-205. Preuzeto s https://hrcak.srce.hr/16757
MLA 8th Edition
BAENA, YOLIMA, et al. "Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents." Acta Pharmaceutica, vol. 55, br. 2, 2005, str. 195-205. https://hrcak.srce.hr/16757. Citirano 23.02.2019.
Chicago 17th Edition
BAENA, YOLIMA, JORGE A. PINZÓN, HELBER J. BARBOSA i FLMING MARTÍNEZ. "Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents." Acta Pharmaceutica 55, br. 2 (2005): 195-205. https://hrcak.srce.hr/16757
Harvard
BAENA, Y., et al. (2005). 'Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents', Acta Pharmaceutica, 55(2), str. 195-205. Preuzeto s: https://hrcak.srce.hr/16757 (Datum pristupa: 23.02.2019.)
Vancouver
BAENA Y, PINZÓN JA, BARBOSA HJ, MARTÍNEZ F. Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents. Acta Pharm. [Internet]. 2005 [pristupljeno 23.02.2019.];55(2):195-205. Dostupno na: https://hrcak.srce.hr/16757
IEEE
Y. BAENA, J.A. PINZÓN, H.J. BARBOSA i F. MARTÍNEZ, "Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents", Acta Pharmaceutica, vol.55, br. 2, str. 195-205, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/16757. [Citirano: 23.02.2019.]

Sažetak
The molar (KCo/w) and rational (KXo/w) partition coefficients in the octanol/buffer, i-propyl myristate/buffer, chloroform/buffer, and cyclohexane/buffer systems were determined for acetanilide and phenacetin at 25.0, 30.0, 35.0, and 40.0 °C. In all cases except for cyclohexane, the KCo/w and KXo/w values were greater than unity. This demonstrates that these two drugs have predominantly lipophilic behavior. Gibbs and van't Hoff thermodynamic analyses have revealed that the transfer of these drugs from water to organic solvents is spontaneous and that it is mainly driven enthalpically for i-propyl myristate and chloroform, and entropy-driven for octanol and cyclohexane.

Ključne riječi
acetanilide; phenacetin; partition coefficient; thermodynamics

Hrčak ID: 16757

URI
https://hrcak.srce.hr/16757

[hrvatski]

Posjeta: 1.021 *