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https://doi.org/10.5562/cca3225

Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives

Selma Zukić ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Elma Veljović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Selma Špirtović-Halilović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Samija Muratović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Amar Osmanović ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Snežana Trifunović ; IHTM, Center for Chemistry, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia
Irena Novaković ; Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia
Davorka Završnik ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina

Puni tekst: engleski, pdf (1 MB) str. 1-9 preuzimanja: 551* citiraj
APA 6th Edition
Zukić, S., Veljović, E., Špirtović-Halilović, S., Muratović, S., Osmanović, A., Trifunović, S., ... Završnik, D. (2018). Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. Croatica Chemica Acta, 91 (1), 1-9. https://doi.org/10.5562/cca3225
MLA 8th Edition
Zukić, Selma, et al. "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives." Croatica Chemica Acta, vol. 91, br. 1, 2018, str. 1-9. https://doi.org/10.5562/cca3225. Citirano 06.03.2021.
Chicago 17th Edition
Zukić, Selma, Elma Veljović, Selma Špirtović-Halilović, Samija Muratović, Amar Osmanović, Snežana Trifunović, Irena Novaković i Davorka Završnik. "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives." Croatica Chemica Acta 91, br. 1 (2018): 1-9. https://doi.org/10.5562/cca3225
Harvard
Zukić, S., et al. (2018). 'Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives', Croatica Chemica Acta, 91(1), str. 1-9. https://doi.org/10.5562/cca3225
Vancouver
Zukić S, Veljović E, Špirtović-Halilović S, Muratović S, Osmanović A, Trifunović S i sur. Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. Croatica Chemica Acta [Internet]. 2018 [pristupljeno 06.03.2021.];91(1):1-9. https://doi.org/10.5562/cca3225
IEEE
S. Zukić, et al., "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives", Croatica Chemica Acta, vol.91, br. 1, str. 1-9, 2018. [Online]. https://doi.org/10.5562/cca3225

Sažetak
Ten biologically active 2,2,5,5-tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, 1H and 13C NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while antifungal activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
xanthene-1,8-diones; antimicrobial activity; antiproliferative activity; antioxidant potency

Hrčak ID: 193597

URI
https://hrcak.srce.hr/193597

Posjeta: 883 *