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DISTRIBUTION OF THE MAIN ABO BLOOD GROUP ALLELES IN CROATIAN POPULATION

IRENA JUKIĆ   ORCID icon orcid.org/0000-0003-2778-8400 ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
JASNA BINGULAC-POPOVIĆ   ORCID icon orcid.org/0000-0002-9449-3154 ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
MARINA SAMARDŽIJA ; University of Osijek, School of Medicine, Osijek, Croatia
MARINA LAMPALO   ORCID icon orcid.org/0000-0001-9264-6922 ; Klinički bolnički centar Zagreb, Klinika za plućne bolesti Jordanovac, Zagreb, Hrvatska
ANA HEĆIMOVIĆ ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
VESNA ĐOGIĆ   ORCID icon orcid.org/0000-0002-6025-4649 ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
MAJA STRAUSS PATKO ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia

Puni tekst: hrvatski, pdf (257 KB) str. 235-240 preuzimanja: 387* citiraj
APA 6th Edition
JUKIĆ, I., BINGULAC-POPOVIĆ, J., SAMARDŽIJA, M., LAMPALO, M., HEĆIMOVIĆ, A., ĐOGIĆ, V. i STRAUSS PATKO, M. (2017). RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI. Acta medica Croatica, 71 (4), 235-240. Preuzeto s https://hrcak.srce.hr/193699
MLA 8th Edition
JUKIĆ, IRENA, et al. "RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI." Acta medica Croatica, vol. 71, br. 4, 2017, str. 235-240. https://hrcak.srce.hr/193699. Citirano 15.09.2019.
Chicago 17th Edition
JUKIĆ, IRENA, JASNA BINGULAC-POPOVIĆ, MARINA SAMARDŽIJA, MARINA LAMPALO, ANA HEĆIMOVIĆ, VESNA ĐOGIĆ i MAJA STRAUSS PATKO. "RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI." Acta medica Croatica 71, br. 4 (2017): 235-240. https://hrcak.srce.hr/193699
Harvard
JUKIĆ, I., et al. (2017). 'RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI', Acta medica Croatica, 71(4), str. 235-240. Preuzeto s: https://hrcak.srce.hr/193699 (Datum pristupa: 15.09.2019.)
Vancouver
JUKIĆ I, BINGULAC-POPOVIĆ J, SAMARDŽIJA M, LAMPALO M, HEĆIMOVIĆ A, ĐOGIĆ V i sur. RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI. Acta medica Croatica [Internet]. 2017 [pristupljeno 15.09.2019.];71(4):235-240. Dostupno na: https://hrcak.srce.hr/193699
IEEE
I. JUKIĆ, et al., "RASPODJELA GLAVNIH ALELA SUSTAVA ABO KRVNIH GRUPA U HRVATSKOJ POPULACIJI", Acta medica Croatica, vol.71, br. 4, str. 235-240, 2017. [Online]. Dostupno na: https://hrcak.srce.hr/193699. [Citirano: 15.09.2019.]

Sažetak
The frequencies of gene polymorphisms of blood groups serve as markers for populations and races. Distribution of ABO blood groups varies among populations and subpopulations around the world. The aim of the study was to determine distribution of the 5 main alleles of ABO system among Croatian blood donors and compare them with other populations. Material and Methods: The study included 303 samples of healthy unrelated volunteer blood donors, 123 female and 180 male, aged 18-65 years, as a representative sample population of Croatia. After isolation of genomic DNA using commercial columns
(QIAamp DNA Blood Mini Kit, Qiagen, Germany) or on the Magna Pure Compact (Roche Diagnostics Corp., USA) device, ABO genotypes were determined by the PCR-SSP method. Results: Twelve of 15 ABO genotypes were identifi ed. The most common was O1O1 (37.30%), followed by O1A1 (27.00%), O1B (15.80%), A1B (4.30%), A1A1 (4.00%), O1A2 (3.60%), O1O2 (2.60%), A1A2 (1.70%), O2A1 (1.70%), A2B (1.00%), BB (0.70%), and O2O2 (0.30%). Three rare ABO genotypes, A2A2, O2A2, and O2B, were not identifi ed. The calculated allele frequencies of the fi ve main alleles were as follows: O1, 0.620; O2, 0,025; A1, 0.21; A2, 0,035; and B, 0.11. In the Croatian population, O1 was found to be the most common allele, followed by A1 and B, while O2 allele was the least prevalent one. Conclusion: The distribution of alleles in Croatia is comparable to other European nations. According to the frequency of B allele, the Croatian population is comparable to Eastern Europe, probably due to migration of the population in the past. Results of ABO blood group genotyping have fundamental importance for research of the ABO system as a genetic risk factor for some diseases, as well as for anthropologic testing.

Ključne riječi
main ABO blood group allele; ABO blood groups; voluntary blood donors

Hrčak ID: 193699

URI
https://hrcak.srce.hr/193699

[hrvatski]

Posjeta: 521 *